Annual report pursuant to Section 13 and 15(d)

Shareholders' Equity / (Deficit) - Additional Information (Details)

Shareholders' Equity / (Deficit) - Additional Information (Details)													1 Months Ended	12 Months Ended			35 Months Ended
	Oct. 17, 2022 USD ($)	Oct. 07, 2022 USD ($) $ / shares	Feb. 12, 2021 $ / shares shares	Feb. 10, 2021 USD ($) $ / shares shares	Feb. 09, 2021 USD ($) $ / shares shares	Feb. 08, 2021 $ / shares shares	Feb. 03, 2021 $ / shares shares	Oct. 31, 2020 $ / shares shares	Oct. 27, 2020 $ / shares shares	Jul. 02, 2020 $ / shares shares	Jun. 05, 2020 $ / shares shares	Jun. 03, 2020 $ / shares shares	Jun. 30, 2020 $ / shares shares	Dec. 31, 2023 USD ($) Vote $ / shares shares	Dec. 31, 2022 USD ($) $ / shares shares	Dec. 31, 2021 USD ($)	Dec. 31, 2023 USD ($) $ / shares shares	May 03, 2023 $ / shares shares	Aug. 17, 2022 $ / shares	Apr. 27, 2018 $ / shares shares
Class Of Stock [Line Items]
Increase to authorized ordinary shares																		60,000,000
Ordinary shares, par value \| $ / shares														$ 0.01	$ 0.01		$ 0.01	$ 0.01	$ 0.01
Ordinary shares, shares authorized														80,000,000	20,000,000		80,000,000
Number of vote per common share \| Vote														1
Common stock shares with preemptive rights														60,000,000			60,000,000
Number of ordinary shares not have preemptive or other subscription rights														20,000,000			20,000,000
Common stock rights and preferences														The holders of ordinary shares currently have preemptive rights over 60,000,000 ordinary shares and no preemptive or other subscription rights over 20,000,000 ordinary shares. There are no redemption or sinking fund provisions with respect to the authorized ordinary shares.
Authorized amount for sale of stock \| $	$ 100,000,000
Ordinary shares, shares issued														13,499,003	12,598,641		13,499,003
Proceeds from registered direct offerings, net of transaction costs \| $														$ 1,034,000	$ 433,000	$ 89,643,000
Aggregate principal amount of exchangeable notes \| $																	$ 40,691,000
Undesignated preferred shares, par value \| $ / shares														$ 0.01	$ 0.01		$ 0.01
Undesignated preferred shares, authorized														100,000,000	100,000,000		100,000,000
Undesignated preferred shares issued														0	0		0
Sales Agreement With H.C. Wainwright
Class Of Stock [Line Items]
Ordinary shares, par value \| $ / shares		$ 0.01
Maximum \| Sales Agreement With H.C. Wainwright
Class Of Stock [Line Items]
May offer and sell ordinary shares for aggregate gross sales proceeds \| $		$ 16,000,000
Private Placement \| Securities Purchase Agreement
Class Of Stock [Line Items]
Number of warrants to purchase ordinary shares											13,868
Warrants to purchase ordinary shares, exercise price \| $ / shares											$ 31.5465	$ 24.3
Warrants expiry date											Jun. 03, 2025	Dec. 05, 2025
Percentage of ordinary shares issued to purchase warrants											7.00%
Private Placement \| Securities Purchase Agreement \| Maximum
Class Of Stock [Line Items]
Number of warrants to purchase ordinary shares												99,057
Private Placement \| June 30 SPA
Class Of Stock [Line Items]
Number of warrants to purchase ordinary shares										15,739				84,317			84,317
Warrants to purchase ordinary shares, exercise price \| $ / shares										$ 27.7965			$ 21.3
Warrants expiry date										Jun. 30, 2025			Jan. 02, 2026
Percentage of ordinary shares issued to purchase warrants										7.00%
Proceeds from exercise of warrants related to registered direct offering \| $														$ 1,796,000
Private Placement \| June 30 SPA \| Maximum
Class Of Stock [Line Items]
Number of warrants to purchase ordinary shares													112,422
October Offering
Class Of Stock [Line Items]
Proceeds from registered direct offerings, net of transaction costs \| $														$ 13,885,000
Number of warrants to purchase ordinary shares								125,641
Number of warrants exercised for ordinary shares														1,392,701			1,392,701
Warrants to purchase ordinary shares, exercise price \| $ / shares								$ 12.1875	$ 9.75
Warrants expiry date								Oct. 22, 2025	Oct. 27, 2025
Percentage of ordinary shares issued to purchase warrants								7.00%
October Offering \| Maximum
Class Of Stock [Line Items]
Number of warrants to purchase ordinary shares									1,346,153
February Underwritten Offering
Class Of Stock [Line Items]
Offering closing date				Feb. 10, 2021		Feb. 08, 2021
Additional ordinary shares that can be purchased by underwriter				347,826
Number of warrants to purchase ordinary shares														25,333			25,333
Warrants to purchase ordinary shares, exercise price \| $ / shares				$ 21.5625		$ 21.5625
Warrants expiry date				Feb. 03, 2026		Feb. 03, 2026
Percentage of ordinary shares issued to purchase warrants				7.00%		7.00%
Proceeds from warrants connected to registered direct offerings \| $														$ 546,000
February Underwritten Offering \| Underwriting Agreement
Class Of Stock [Line Items]
Ordinary shares, par value \| $ / shares							$ 0.01
Ordinary shares, shares issued							2,318,840
Offering closing date							Feb. 08, 2021
February Underwritten Offering \| Pursuant to the Underwriting Agreement
Class Of Stock [Line Items]
Ordinary shares, shares issued				2,666,666
Additional ordinary shares that can be purchased by underwriter				347,826
Aggregate gross proceeds from ordinary shares \| $				$ 46,000,000
Proceeds from registered direct offerings, net of transaction costs \| $				$ 42,119,000
February Underwritten Offering \| Maximum
Class Of Stock [Line Items]
Number of warrants to purchase ordinary shares				24,347		162,318
February 2021 Underwritten Offering \| Underwriting Agreement
Class Of Stock [Line Items]
Offering price per share \| $ / shares							$ 17.25
At-the-market Agreement
Class Of Stock [Line Items]
Number of ordinary shares sold														639,825	356,933
Offering price per share \| $ / shares														$ 1.68	$ 1.25		$ 1.68
Proceeds from registered direct offerings, net of transaction costs \| $														$ 1,000,000	$ 400,000
February Registered Direct Offering
Class Of Stock [Line Items]
Ordinary shares, par value \| $ / shares					$ 0.01
Ordinary shares, shares issued					1,166,666
Offering price per share \| $ / shares					$ 30
Offering closing date			Feb. 12, 2021		Feb. 12, 2021
Aggregate gross proceeds from ordinary shares \| $					$ 35,000,000
Proceeds from registered direct offerings, net of transaction costs \| $					$ 32,235,000
Number of warrants to purchase ordinary shares			81,666
Warrants to purchase ordinary shares, exercise price \| $ / shares			$ 37.5
Warrants expiry date			Feb. 09, 2026
Percentage of ordinary shares issued to purchase warrants			7.00%
Warrants to Purchase 19,890 Ordinary Shares \| Silicon Valley Bank and Life Sciences Fund II LLC
Class Of Stock [Line Items]
Warrants expiry date														Apr. 27, 2028
Series B Convertible Preferred Shares \| Silicon Valley Bank and Life Sciences Fund II LLC
Class Of Stock [Line Items]
Number of warrants to purchase ordinary shares														19,890			19,890			19,890
Warrants to purchase ordinary shares, exercise price \| $ / shares														$ 282.75			$ 282.75			$ 282.75
Undesignated Preferred Shares
Class Of Stock [Line Items]
Undesignated preferred shares, par value \| $ / shares														$ 0.01			$ 0.01
Undesignated preferred shares, authorized														100,000,000			100,000,000
Undesignated preferred shares issued														0	0		0
Ordinary Shares \| Silicon Valley Bank and Life Sciences Fund II LLC
Class Of Stock [Line Items]
Number of warrants to purchase ordinary shares														1,326			1,326			1,326
Exchangeable Notes
Class Of Stock [Line Items]
Ordinary shares, shares issued														3,760,155			3,760,155
Aggregate principal amount of exchangeable notes \| $																	$ 40,691,000
Aggregate principal amount \| $														$ 11,117,000			11,117,000
Exchangeable Notes \| Private Placement
Class Of Stock [Line Items]
Aggregate principal amount of exchangeable notes \| $																	$ 40,691,000