During the three months ended December 31, 2023, our Chief Medical Officer Dr. Puttagunta terminated an instruction for the sale of securities that was intended to satisfy the affirmative defense conditions of Rule 10b5-1(c) of the Exchange Act or any non-Rule 10b5-1 trading arrangement (as defined in the Securities and Exchange Commission’s rules). The automatic sale instructions were executed by Dr. Puttagunta on December 12, 2021 in connection with the grant of 33,333 restricted share units vesting over four years, with 25% of the restricted share units fully vesting on each one-year anniversary of December 1, 2021 (the “RSU Grant”). The

automatic sale instructions covered such number of ordinary shares issuable with respect to the restricted share units vesting on each relevant vesting date as was sufficient to generate net proceeds sufficient to satisfy the Company's minimum statutory withholding obligations with respect to the income recognized by Dr. Puttagunta upon the vesting of such restricted share units (based on minimum statutory withholding rates for all tax purposes, including payroll and social taxes, applicable to such income). The termination covered the automatic sale instructions given with respect to 24,999 restricted share units included in the RSU Grant vesting over the remaining 3 year vesting period, on December 1, 2023, December 1, 2024 and December 1, 2025.