Annual report pursuant to Section 13 and 15(d)

Share-Based Compensation - Summary of Number of Options Outstanding and Weighted-average Exercise Price (Details)

v3.22.4
Share-Based Compensation - Summary of Number of Options Outstanding and Weighted-average Exercise Price (Details) - USD ($)
$ / shares in Units, $ in Thousands
12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Compensation Related Costs [Abstract]        
Number of Shares, Options outstanding Beginning Balance 1,068,639 63,431 76,636  
Number of Shares, Granted 197,085 1,028,090 4,322  
Number of Shares, Forfeited (3,333)   (9,260)  
Number of Shares, Cancelled (906,800)      
Number of Shares, Expired   (22,882) (8,267)  
Number of Shares, Options outstanding Ending Balance 355,591 1,068,639 63,431 76,636
Number of Shares, Exercisable at December 31, 2020 59,392      
Weighted Average Exercise Price, Options outstanding Beginning Balance $ 30.12 $ 110.40 $ 118.79  
Weighted Average Exercise Price, Granted 2.88 27.13 25.36  
Weighted Average Exercise Price, Forfeited 6.15   129.07  
Weighted Average Exercise Price, Cancelled 33.16      
Weighted Average Exercise Price, Expired   118.49 122.83  
Weighted Average Exercise Price, Options outstanding Ending Balance 7.49 $ 30.12 $ 110.40 $ 118.79
Weighted Average Exercise Price, Exercisable at December 31, 2020 $ 22.21      
Weighted Average Remaining Contractual Life in Years, Options outstanding 9 years 1 month 13 days 9 years 5 months 1 day 5 years 4 months 28 days 8 years 7 months 2 days
Weighted Average Remaining Contractual Life in Years, Exercisable at December 31, 2019 8 years 1 month 2 days      
Aggregate Intrinsic Value, Options outstanding     $ 254  
Aggregate Intrinsic Value, Options outstanding       $ 254