Annual report pursuant to Section 13 and 15(d)

Summary of Significant Accounting Policies (Tables)

Summary of Significant Accounting Policies (Tables)

12 Months Ended

Dec. 31, 2022

Schedule of Property and Equipment Depreciated Using the Straight-Line Method Over the Estimated Useful Life of Each Asset

Property and equipment are stated at cost less accumulated depreciation. Property and equipment are depreciated using the straight-line method over the estimated useful life of each asset as follows:


	Estimated Useful Life
Leasehold improvements	Shorter of life of lease or 10 years
Furniture and fixtures	5 years
Laboratory equipment	5 years
Computer equipment	3 years

Schedule of Potentially Dilutive Securities Excluded from Computation of Diluted Weighted-Average Shares Outstanding

For the periods presented, the following ordinary shares underlying the options, unvested restricted share units, unvested performance restricted share units, warrants and the Exchangeable Notes have been excluded from the calculation because they would be anti-dilutive.


	Year ended December 31,
	2022		2021		2020
Options to purchase ordinary shares		355,591		1,068,639		63,431
Unvested restricted share units		128,728		119,017		—
Unvested performance restricted share units		—		—		65,527
Warrants		480,186		480,186		1,629,619
Exchangeable Notes		1,287,660		1,217,386		4,715,004
Total		2,252,165		2,885,228		6,473,581

Schedule of Distribution of Total Operating Expenses by Geographical Area

The distribution of total operating expenses by geographical area was as follows:


	Year ended December 31,
Operating expenses	2022		2021		2020
Ireland	$	22,015	$	15,926	$	23,423
U.S.		8,332		8,554		8,703
Bermuda		36		57		—
Total	$	30,383	$	24,537	$	32,126

Schedule of Distribution of Long-Lived Assets by Geographical Area

The distribution of long-lived assets by geographical area was as follows:


Long lived assets	December 31, 2022		December 31, 2021
Ireland	$	4,052	$	7,601
U.S.		303		578
Total	$	4,355	$	8,179