Annual report pursuant to Section 13 and 15(d)

Shareholders' Equity / (Deficit) - Additional Information (Details)

Shareholders' Equity / (Deficit) - Additional Information (Details)													1 Months Ended	12 Months Ended	23 Months Ended
	Oct. 17, 2022 USD ($)	Oct. 07, 2022 USD ($) $ / shares	Feb. 12, 2021 $ / shares shares	Feb. 10, 2021 USD ($) $ / shares shares	Feb. 09, 2021 USD ($) $ / shares shares	Feb. 08, 2021 $ / shares shares	Feb. 03, 2021 $ / shares shares	Oct. 31, 2020 $ / shares shares	Oct. 27, 2020 $ / shares shares	Jul. 02, 2020 $ / shares shares	Jun. 05, 2020 $ / shares shares	Jun. 03, 2020 $ / shares shares	Jun. 30, 2020 $ / shares shares	Dec. 31, 2022 USD ($) Vote $ / shares shares	Dec. 31, 2022 USD ($) $ / shares shares	Aug. 17, 2022 $ / shares	Dec. 31, 2021 $ / shares shares	Jan. 28, 2021 $ / shares shares	Apr. 27, 2018 $ / shares shares
Class Of Stock [Line Items]
Increase to authorized ordinary shares																		10,000,000
Ordinary shares, par value \| $ / shares														$ 0.01	$ 0.01	$ 0.01	$ 0.01	$ 0.01
Ordinary shares, shares authorized														20,000,000	20,000,000		20,000,000
Number of vote per common share \| Vote														1
Common stock rights and preferences														The holders of ordinary shares currently have no preemptive or other subscription rights, and there are no redemption or sinking fund provisions with respect to such shares.
Authorized amount for sale of stock \| $	$ 100,000,000.0
Ordinary shares, shares issued														12,598,641	12,598,641		12,185,019
Number of warrants to purchase ordinary shares														25,333	25,333
Proceeds from warrants connected to registered direct offerings \| $														$ 546,000
Undesignated preferred shares, par value \| $ / shares														$ 0.01	$ 0.01		$ 0.01
Undesignated preferred shares, authorized														100,000,000	100,000,000		100,000,000
Undesignated preferred shares issued														0	0		0
Sales Agreement With H.C. Wainwright
Class Of Stock [Line Items]
Ordinary shares, par value \| $ / shares		$ 0.01
Maximum \| Sales Agreement With H.C. Wainwright
Class Of Stock [Line Items]
May offer and sell ordinary shares for aggregate gross sales proceeds \| $		$ 16,000,000.0
Private Placement \| Securities Purchase Agreement
Class Of Stock [Line Items]
Number of warrants to purchase ordinary shares											13,868
Warrants to purchase ordinary shares, exercise price \| $ / shares											$ 31.5465	$ 24.30
Warrants expiry date												Dec. 05, 2025
Percentage of ordinary shares issued to purchase warrants											7.00%
Private Placement \| Securities Purchase Agreement \| Maximum
Class Of Stock [Line Items]
Number of warrants to purchase ordinary shares												99,057
Private Placement \| June 30 SPA
Class Of Stock [Line Items]
Number of warrants to purchase ordinary shares										15,739				84,317	84,317
Warrants to purchase ordinary shares, exercise price \| $ / shares										$ 27.7965			$ 21.30
Warrants expiry date										Jun. 30, 2025			Jan. 02, 2026
Percentage of ordinary shares issued to purchase warrants										7.00%
Proceeds from exercise of warrants related to registered direct offering \| $														$ 1,796,000
Private Placement \| June 30 SPA \| Maximum
Class Of Stock [Line Items]
Number of warrants to purchase ordinary shares													112,422
October Offering
Class Of Stock [Line Items]
Proceeds from registered direct offerings, net of transaction costs \| $														$ 13,885,000
Number of warrants to purchase ordinary shares								125,641						1,392,701	1,392,701
Warrants to purchase ordinary shares, exercise price \| $ / shares								$ 12.1875	$ 9.75
Warrants expiry date								Oct. 22, 2025	Oct. 27, 2025
Percentage of ordinary shares issued to purchase warrants								7.00%
October Offering \| Maximum
Class Of Stock [Line Items]
Number of warrants to purchase ordinary shares									1,346,153
February Underwritten Offering
Class Of Stock [Line Items]
Offering closing date				Feb. 10, 2021		Feb. 08, 2021
Additional ordinary shares that can be purchased by underwriter				347,826
Warrants to purchase ordinary shares, exercise price \| $ / shares				$ 21.5625		$ 21.5625
Warrants expiry date				Feb. 03, 2026		Feb. 03, 2026
Percentage of ordinary shares issued to purchase warrants				7.00%		7.00%
February Underwritten Offering \| Underwriting Agreement
Class Of Stock [Line Items]
Ordinary shares, par value \| $ / shares							$ 0.01
Ordinary shares, shares issued							2,318,840
Offering closing date							Feb. 08, 2021
February Underwritten Offering \| Pursuant to the Underwriting Agreement
Class Of Stock [Line Items]
Ordinary shares, shares issued				2,666,666
Additional ordinary shares that can be purchased by underwriter				347,826
Aggregate gross proceeds from ordinary shares \| $				$ 46,000,000
Proceeds from registered direct offerings, net of transaction costs \| $				$ 42,119,000
February Underwritten Offering \| Maximum
Class Of Stock [Line Items]
Number of warrants to purchase ordinary shares				24,347		162,318
February 2021 Underwritten Offering \| Underwriting Agreement
Class Of Stock [Line Items]
Offering price per share \| $ / shares							$ 17.25
At-the-market Agreement
Class Of Stock [Line Items]
Number of ordinary shares sold														356,933
Offering price per share \| $ / shares														$ 1.25	$ 1.25
Proceeds from registered direct offerings, net of transaction costs \| $														$ 400,000
February Registered Direct Offering
Class Of Stock [Line Items]
Ordinary shares, par value \| $ / shares					$ 0.01
Ordinary shares, shares issued					1,166,666
Offering price per share \| $ / shares					$ 30.00
Offering closing date			Feb. 12, 2021		Feb. 12, 2021
Aggregate gross proceeds from ordinary shares \| $					$ 35,000,000
Proceeds from registered direct offerings, net of transaction costs \| $					$ 32,235,000
Warrants to purchase ordinary shares, exercise price \| $ / shares			$ 37.50
Warrants expiry date			Feb. 09, 2026
Percentage of ordinary shares issued to purchase warrants			7.00%
February Registered Direct Offering \| Maximum
Class Of Stock [Line Items]
Number of warrants to purchase ordinary shares			81,666
Warrants to Purchase 19,890 Ordinary Shares
Class Of Stock [Line Items]
Warrants expiry date														Apr. 27, 2028
Series B Convertible Preferred Shares \| Silicon Valley Bank and Life Sciences Fund II LLC
Class Of Stock [Line Items]
Number of warrants to purchase ordinary shares														19,890	19,890				19,890
Warrants to purchase ordinary shares, exercise price \| $ / shares														$ 282.75	$ 282.75				$ 282.75
Undesignated Preferred Shares
Class Of Stock [Line Items]
Undesignated preferred shares, par value \| $ / shares														$ 0.01	$ 0.01
Undesignated preferred shares, authorized														100,000,000	100,000,000
Undesignated preferred shares issued														0	0		0
Ordinary Shares
Class Of Stock [Line Items]
Number of warrants to purchase ordinary shares														1,326	1,326				1,326
Exchangeable Notes
Class Of Stock [Line Items]
Ordinary shares, shares issued														3,592,555	3,592,555
Aggregate principal amount of exchangeable notes \| $															$ 39,201,000
Aggregate principal amount \| $														$ 12,607,000	12,607,000
Exchangeable Notes \| Private Placement
Class Of Stock [Line Items]
Aggregate principal amount of exchangeable notes \| $															$ 39,201,000