Annual report pursuant to Section 13 and 15(d)

Share-Based Compensation - Additional Information (Details)

Share-Based Compensation - Additional Information (Details) - USD ($) $ / shares in Units, $ in Thousands									12 Months Ended
	Jul. 07, 2022	Nov. 24, 2021	Jun. 22, 2021	Jun. 10, 2020	Feb. 14, 2020	Dec. 31, 2018	Dec. 05, 2018	Nov. 18, 2015	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020	Jun. 23, 2021	Dec. 31, 2019	Mar. 14, 2018
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of Shares, Cancelled									(906,800)
Cancellation Of Share Option									$ 17,350
Share options granted									197,085	1,028,090	4,322
Weighted average grant date fair value, options granted									$ 2.39	$ 23.67	$ 19.17
Employee Stock Options
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Risk-free interest rate based on estimate of U.S. treasury yield									7 years
Employees and Directors
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Expense recognized									$ 3,580	$ 3,779	$ 1,136
Vesting period									1 year 4 months 28 days	3 years 5 months 26 days	1 year 5 months 19 days
Share options granted									197,085	1,028,090	4,322
Unvested employee options outstanding									296,199	1,033,820	17,778
Unamortized compensation expense share options									$ 929	$ 21,521	$ 970
Restricted Share Units (RSUs)
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Grant date fair value									$ 9.87	$ 19.16			$ 105.21
Expense recognized									$ 1,178	$ 960	$ 63
Number of shares, granted/awarded									66,398	123,017
Unamortized compensation expense									$ 434	$ 1,416
Stock-based compensation expense, expected weighted average period for recognition									10 months 17 days	1 year 10 months 20 days
Restricted Share Units (RSUs) \| Employees and Directors
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of shares, granted/awarded									66,398	123,017	0
Restricted Share Units (RSUs) \| Director
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Vesting period									1 year
Performance RSUs
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Grant date fair value											$ 33.18		$ 123.15
Expense recognized										$ (0)	$ 1,560
Number of shares, granted/awarded									0	0	71,927
Unamortized compensation expense											$ 152
Stock-based compensation expense, expected weighted average period for recognition											2 months 12 days
Performance RSUs \| Employees
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of shares, granted/awarded											71,927
Restricted Ordinary Shares, Options and Restricted Share Units and Performance Restricted Share Units
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Vesting period									1 year 3 months 10 days	3 years 3 months 25 days	9 months 18 days
Unamortized compensation expense									$ 1,363	$ 22,937	$ 1,122
2015 Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of shares authorized								14,895
Number of ordinary shares available for issuance								29,535
Increase in number of ordinary shares available for issuance								14,640
2018 Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of shares authorized												1,295,819		67,897
Increase in number of ordinary shares available to be granted, percentage					4.00%		4.00%
Increase in number of ordinary shares available to be granted			1,000,000	150,000	39,650	38,272
2018 Plan \| Restricted Share Units (RSUs) \| Employees
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Vesting period									2 years
2021 Inducement Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Increase in number of ordinary shares available to be granted		333,333
2021 Inducement Plan \| Restricted Share Units (RSUs) \| Employees
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Vesting period									4 years
2015 Plan, 2018 Plan and 2021 Inducement Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of Shares, Cancelled									(906,800)
Share options granted									197,085	1,028,090	4,322
2015 Plan, 2018 Plan and 2021 Inducement Plan \| Employee Stock Options
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share option granted term									10 years
Vesting period									4 years
Vesting rights									The vesting requirement is conditioned upon a grantee’s continued service with the Company during the vesting period. Once vested, all awards are exercisable from the date of grant until they expire. The option grants are non-transferable. Vested options generally remain exercisable for 90 days subsequent to the termination of the option holder’s service with the Company. In the event of an option holder’s disability or death while employed by or providing service to the Company, the exercisable period extends to twelve months or eighteen months, respectively.
2015 Plan, 2018 Plan and 2021 Inducement Plan \| Restricted Share Units (RSUs)
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of shares, granted/awarded									66,398	123,017
Two Thousand Twenty One Inducement Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share options granted									6,332	120,000
Two Thousand Twenty One Inducement Plan \| Restricted Share Units (RSUs)
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of shares, granted/awarded										33,333
Amended And Restated 2018 Equity Incentive Plan [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of Shares, Cancelled	906,800
Amended And Restated 2018 Equity Incentive Plan [Member] \| Employee Stock Options
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Cancellation Of Share Option									$ 17,350