Annual report pursuant to Section 13 and 15(d)

Quarterly Financial Data (Unaudited) - Schedule of Unaudited Quarterly Financial Data (Details)

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Quarterly Financial Data (Unaudited) - Schedule of Unaudited Quarterly Financial Data (Details) - USD ($)
 3 Months Ended 12 Months Ended
Dec. 31, 2020
Sep. 30, 2020
Jun. 30, 2020
Mar. 31, 2020
Dec. 31, 2019
Sep. 30, 2019
Jun. 30, 2019
Mar. 31, 2019
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Quarterly Financial Information Disclosure [Abstract]                      
Revenue               $ 37,000 $ 0 $ 37,000 $ 869,000
Total operating expenses $ (4,644,000) $ (6,335,000) $ (8,253,000) $ (12,894,000) $ (23,178,000) $ (30,999,000) $ (27,378,000) (20,503,000) (32,126,000) (102,058,000) (77,428,000)
Net loss (11,186,000) (12,199,000) (12,521,000) (16,100,000) (23,641,000) (31,271,000) (27,638,000) (20,580,000) (52,006,000) (103,130,000) (77,056,000)
Net loss attributable to ordinary shareholders $ (11,186,000) $ (12,199,000) $ (12,521,000) $ (16,100,000) $ (23,641,000) $ (31,271,000) $ (27,638,000) $ (20,580,000) $ (52,006,000) $ (103,130,000) $ (77,056,000)
Net loss per share attributable to ordinary shareholders – basic and diluted $ (0.28) $ (0.60) $ (0.80) $ (1.08) $ (1.59) $ (2.15) $ (1.93) $ (1.44) $ (2.17) $ (7.10) $ (8.82)
Weighted average ordinary shares outstanding – basic and diluted 40,645,864 20,392,357 15,614,767 14,868,973 14,866,838 14,571,278 14,340,231 14,290,437 24,009,818 14,518,036 8,734,109