Annual report pursuant to Section 13 and 15(d)

Summary of Significant Accounting Policies (Tables)

Summary of Significant Accounting Policies (Tables)

12 Months Ended

Dec. 31, 2020

Schedule of Property and Equipment Depreciated Using the Straight-Line Method Over the Estimated Useful Life of Each Asset

Property and equipment are stated at cost less accumulated depreciation. Property and equipment are depreciated using the straight-line method over the estimated useful life of each asset as follows:

	Estimated Useful Life
Leasehold improvements	Shorter of life of lease or 10 years
Furniture and fixtures	5 years
Laboratory equipment	5 years
Computer equipment	3 years

Schedule of Potentially Dilutive Securities Excluded from Computation of Diluted Weighted-Average Shares Outstanding

The following potentially dilutive securities have been excluded from the computation of diluted weighted-average shares outstanding as they would be anti-dilutive:

	Year ended December 31,
	2020		2019		2018
Options to purchase ordinary shares		953,377		1,150,270		665,219
Unvested restricted ordinary shares		—		—		86,068
Unvested restricted share units		—		31,367		36,924
Unvested performance restricted share units		983,000		50,000		—
Warrants		24,444,292		19,890		19,890
Total		26,380,669		1,251,527		808,101

Schedule of Distribution of Total Operating Expenses by Geographical Area

The distribution of total operating expenses by geographical area was as follows:

	Year ended December 31,
Operating expenses	2020		2019		2018
Ireland	$	23,423	$	90,792	$	66,552
U.S.		8,703		11,266		10,876
Total	$	32,126	$	102,058	$	77,428

Schedule of Distribution of Long-Lived Assets by Geographical Area

The distribution of long-lived assets by geographical area was as follows:

Long lived assets	December 31, 2020		December 31, 2019
Ireland	$	8,101	$	10,936
U.S.		2,971		3,037
Total	$	11,072	$	13,973