Summary of Significant Accounting Policies - Schedule of Distribution of Total Operating Expenses by Geographical Area (Details) - USD ($) $ in Thousands	3 Months Ended								12 Months Ended
	Dec. 31, 2020	Sep. 30, 2020	Jun. 30, 2020	Mar. 31, 2020	Dec. 31, 2019	Sep. 30, 2019	Jun. 30, 2019	Mar. 31, 2019	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Segment Reporting Information [Line Items]
Operating expenses	$ 4,644	$ 6,335	$ 8,253	$ 12,894	$ 23,178	$ 30,999	$ 27,378	$ 20,503	$ 32,126	$ 102,058	$ 77,428
Ireland
Segment Reporting Information [Line Items]
Operating expenses									23,423	90,792	66,552
U.S.
Segment Reporting Information [Line Items]
Operating expenses									$ 8,703	$ 11,266	$ 10,876