Annual report pursuant to Section 13 and 15(d)

Summary of Significant Accounting Policies - Schedule of Distribution of Total Operating Expenses by Geographical Area (Details)

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Summary of Significant Accounting Policies - Schedule of Distribution of Total Operating Expenses by Geographical Area (Details) - USD ($)
$ in Thousands
3 Months Ended 12 Months Ended
Dec. 31, 2019
Sep. 30, 2019
Jun. 30, 2019
Mar. 31, 2019
Dec. 31, 2018
Sep. 30, 2018
Jun. 30, 2018
Mar. 31, 2018
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Segment Reporting Information [Line Items]                      
Operating expenses $ 23,178 $ 30,999 $ 27,378 $ 20,503 $ 24,183 $ 25,240 $ 15,611 $ 12,394 $ 102,058 $ 77,428 $ 29,963
Ireland                      
Segment Reporting Information [Line Items]                      
Operating expenses                 90,792 66,552 24,619
U.S.                      
Segment Reporting Information [Line Items]                      
Operating expenses                 $ 11,266 $ 10,876 $ 5,344