Annual report pursuant to Section 13 and 15(d)

Consolidated Statements of Convertible Preferred Shares and Shareholders' (Deficit) / Equity

Consolidated Statements of Convertible Preferred Shares and Shareholders' (Deficit) / Equity - USD ($) $ in Thousands	Total	Convertible Preferred Stock	Series B Convertible Preferred Shares	IPO	Ordinary Shares	Ordinary Shares Convertible Preferred Stock	Ordinary Shares IPO	Additional Paid-In Capital	Additional Paid-In Capital IPO	Accumulated Deficit
Beginning balance at Dec. 31, 2016	$ 22,668				$ 4			$ 47,995		$ (25,331)
Temporary Equity beginning balance (in shares) at Dec. 31, 2016		3,032,457
Temporary Equity beginning balance at Dec. 31, 2016		$ 30
Beginning balance (in shares) at Dec. 31, 2016					413,110
Issuance of Series B convertible preferred shares, net of issuance costs	45,840							45,840
Temporary equity,Issuance of shares (in shares)			2,654,206
Temporary equity,Issuance of shares			$ 27
Share-based compensation expense	392							392
Net loss	(29,406)									(29,406)
Ending balance at Dec. 31, 2017	39,494				$ 4			94,227		(54,737)
Temporary Equity ending balance (in shares) at Dec. 31, 2017		5,686,663
Temporary Equity ending balance at Dec. 31, 2017		$ 57
Ending balance (in shares) at Dec. 31, 2017					413,110
Issuance of Series B convertible preferred shares, net of issuance costs	32,159							32,159
Temporary equity,Issuance of shares (in shares)			1,709,650
Temporary equity,Issuance of shares			$ 17
Issuance of shares				$ 74,153			$ 64		$ 74,089
Issuance of shares (in shares)							6,350,000
Exercise of share options	$ 7							7
Exercise of share options (in shares)	2,008				2,008
Issuance of ordinary shares under subscription agreement	$ 1,362				$ 2			1,360
Issuance of ordinary shares under subscription agreement (in shares)					190,615
Redenomination of share capital	(42)					$ (42)
Temporary equity,redenomination of share capital		$ 42
Conversion of preferred shares to ordinary shares	116				$ 116
Temporary equity conversion of convertible preferred stock (in shares)		(7,396,313)
Temporary equity conversion of convertible preferred stock		$ (116)
Conversion of preferred shares to ordinary shares (in shares)					7,396,313
Issuance of warrants for ordinary shares	139							139
Share-based compensation expense	1,290							1,290
Net loss	(77,056)									(77,056)
Ending balance at Dec. 31, 2018	71,622				$ 144			203,271		(131,793)
Ending balance (in shares) at Dec. 31, 2018					14,352,046
Issuance of ordinary shares in conjunction with vesting of restricted share units (in shares)					36,924
Exercise of share options	$ 60							60
Exercise of share options (in shares)	18,232				18,232
Issuance of ordinary shares under subscription agreement	$ 3,037				$ 5			3,032
Issuance of ordinary shares under subscription agreement (in shares)					461,771
Share-based compensation expense	2,173							2,173
Net loss	(103,130)									(103,130)
Ending balance at Dec. 31, 2019	$ (26,238)				$ 149			$ 208,536		$ (234,923)
Ending balance (in shares) at Dec. 31, 2019					14,868,973