Annual report pursuant to Section 13 and 15(d)

Summary of Significant Accounting Policies (Tables)

Summary of Significant Accounting Policies (Tables)

12 Months Ended

Dec. 31, 2019

Schedule of Property and Equipment Depreciated Using the Straight-Line Method Over the Estimated Useful Life of Each Asset

Property and equipment are stated at cost less accumulated depreciation. Property and equipment are depreciated using the straight-line method over the estimated useful life of each asset as follows:

	Estimated Useful Life
Leasehold improvements	Shorter of life of lease or 10 years
Furniture and fixtures	5 years
Laboratory equipment	5 years
Computer equipment	3 years

Schedule of Potentially Dilutive Securities Excluded from Computation of Diluted Weighted-Average Shares Outstanding

The following potentially dilutive securities have been excluded from the computation of diluted weighted-average shares outstanding as they would be anti-dilutive:

	Year ended December 31,
	2019		2018		2017
Options to purchase ordinary shares		1,150,270		665,219		248,128
Preferred shares convertible into ordinary shares		—		—		5,686,663
Unvested restricted ordinary shares		—		86,068		189,342
Unvested restricted share units		31,367		36,924		—
Unvested performance restricted share units		50,000		—		—
Warrants		19,890		19,890		—
Total		1,251,527		808,101		6,124,133

Schedule of Distribution of Total Operating Expenses by Geographical Area

The distribution of total operating expenses by geographical area was as follows:

	Year ended December 31,
Operating expenses	2019		2018		2017
Ireland	$	90,792	$	66,552	$	24,619
U.S.		11,266		10,876		5,344
Total	$	102,058	$	77,428	$	29,963

Schedule of Distribution of Long-Lived Assets by Geographical Area

The distribution of long-lived assets by geographical area was as follows:

Long lived assets	December 31, 2019		December 31, 2018
Ireland	$	10,936	$	4,565
U.S.		3,037		245
Total	$	13,973	$	4,810