Annual report pursuant to Section 13 and 15(d)

Commitment and Contingencies - Additional Information (Details)

v3.19.1
Commitment and Contingencies - Additional Information (Details) - USD ($)
 1 Months Ended
Jun. 30, 2018
Mar. 31, 2018
Apr. 30, 2017
Dec. 31, 2016
Dec. 31, 2018
Dec. 31, 2017
Jun. 30, 2016
Nov. 18, 2015
Other Commitments [Line Items]                
Purchase obligation         $ 1,604,000 $ 599,000 $ 2,864,000  
Pfizer License Agreement | Minimum                
Other Commitments [Line Items]                
Potential future regulatory milestone and sales milestone payments upon achievement of net sales               $ 250,000,000
Pfizer License Agreement | Maximum                
Other Commitments [Line Items]                
Potential future regulatory milestone and sales milestone payments upon achievement of net sales               $ 1,000,000,000
Supplemental Agreement                
Other Commitments [Line Items]                
Purchase obligation $ 2,348,000              
Commercial Unit Lease Agreement | Dublin                
Other Commitments [Line Items]                
Operating lease agreement, term of contract 20 years              
Operating lease agreement, break option term of contract 10 years              
Operating lease agreement, commencement period 2018-06              
Annual lease payments $ 315,000              
Operating lease agreement, rental review 5 years              
Security deposit $ 802,000              
Office Space Lease Agreement | Dublin                
Other Commitments [Line Items]                
Operating lease agreement, term of contract       10 years        
Annual lease payments       $ 331,000        
Operating lease agreement, renewal term       5 years        
Lessee operating lease agreement expiration period       10 years        
Operating lease agreement, commencement date       Dec. 01, 2016        
Operating lease agreement, review period       2022-12        
Office Space Lease Agreement | Dublin | Other Assets                
Other Commitments [Line Items]                
Security deposit       $ 331,000        
Office Space Lease Agreement | Chicago                
Other Commitments [Line Items]                
Operating lease agreement, term of contract   5 years            
Operating lease agreement, commencement period   2018-06            
Annual lease payments   $ 258,000            
Security deposit   $ 120,000            
Operating lease agreement, renewal term   5 years            
Office Space Lease Agreement | Connecticut                
Other Commitments [Line Items]                
Operating lease agreement, term of contract     5 years          
Operating lease agreement, commencement period     2017-07          
Annual lease payments     $ 131,000          
Operating lease agreement, renewal term     3 years          
Office Space Lease Agreement | Connecticut | Other Assets                
Other Commitments [Line Items]                
Security deposit     $ 17,000