Annual report pursuant to Section 13 and 15(d)

Consolidated Statements of Convertible Preferred Shares and Shareholders' Equity

Consolidated Statements of Convertible Preferred Shares and Shareholders' Equity - USD ($) $ in Thousands	Total	Convertible Preferred Stock	Series A Convertible Preferred Shares	Series B Convertible Preferred Shares	IPO	Ordinary Shares	Ordinary Shares Convertible Preferred Stock	Ordinary Shares IPO	Preferred Shares	Additional Paid-In Capital	Additional Paid-In Capital IPO	Accumulated Deficit
Beginning balance at Dec. 31, 2015	$ 14,950					$ 4				$ 23,813		$ (11,867)
Temporary Equity beginning balance (in shares) at Dec. 31, 2015		1,514,320
Temporary Equity beginning balance at Dec. 31, 2015		$ 15
Beginning balance (in shares) at Dec. 31, 2015						413,110			3,000
Issuance of shares	20,834									23,834
Temporary equity,Issuance of shares (in shares)			1,518,137
Temporary equity,Issuance of shares			$ 15
Issuance of shares (in shares)									(3,000)
Share-based compensation expense	348									348
Net loss	(13,464)											(13,464)
Ending balance at Dec. 31, 2016	22,668					$ 4				47,995		(25,331)
Temporary Equity ending balance (in shares) at Dec. 31, 2016		3,032,457
Temporary Equity ending balance at Dec. 31, 2016		$ 30
Ending balance (in shares) at Dec. 31, 2016						413,110
Temporary equity,Issuance of shares (in shares)				2,654,206
Temporary equity,Issuance of shares				$ 27
Issuance of Series B convertible preferred shares, net of issuance costs	45,840									45,840
Share-based compensation expense	392									392
Net loss	(29,406)											(29,406)
Ending balance at Dec. 31, 2017	39,494					$ 4				94,227		(54,737)
Temporary Equity ending balance (in shares) at Dec. 31, 2017		5,686,663
Temporary Equity ending balance at Dec. 31, 2017		$ 57	$ 30	$ 27
Ending balance (in shares) at Dec. 31, 2017						413,110
Issuance of shares					$ 74,153			$ 64			$ 74,089
Temporary equity,Issuance of shares (in shares)				1,709,650
Temporary equity,Issuance of shares				$ 17
Issuance of shares (in shares)								6,350,000
Issuance of Series B convertible preferred shares, net of issuance costs	32,159									32,159
Exercise of share options	$ 7									7
Exercise of share options (in shares)	2,008					2,008
Issuance of ordinary shares under subscription agreement	$ 1,362					$ 2				1,360
Issuance of ordinary shares under subscription agreement (in shares)						190,615
Redenomination of share capital	(42)						$ (42)
Temporary equity,redenomination of share capital		$ 42
Conversion of preferred shares to ordinary shares	116					$ 116
Temporary equity conversion of convertible preferred stock (in shares)		(7,396,313)
Temporary equity conversion of convertible preferred stock		$ (116)
Conversion of preferred shares to ordinary shares (in shares)						7,396,313
Issuance of warrants for ordinary shares	139									139
Share-based compensation expense	1,290									1,290
Net loss	(77,056)											(77,056)
Ending balance at Dec. 31, 2018	$ 71,622					$ 144				$ 203,271		$ (131,793)
Ending balance (in shares) at Dec. 31, 2018						14,352,046