Summary of Significant Accounting Policies (Tables)

Summary of Significant Accounting Policies (Tables)

12 Months Ended

Dec. 31, 2018

Schedule of Property and Equipment Depreciated Using the Straight-Line Method Over the Estimated Useful Life of Each Asset

Property and equipment are stated at cost less accumulated depreciation. Property and equipment are depreciated using the straight-line method over the estimated useful life of each asset as follows:

	Estimated Useful Life
Leasehold improvements	Shorter of life of lease or 10 years
Furniture and fixtures	5 years
Laboratory equipment	5 years
Computer equipment	3 years

Schedule of Potentially Dilutive Securities Excluded from Computation of Diluted Weighted-Average Shares Outstanding

The following potentially dilutive securities have been excluded from the computation of diluted weighted-average shares outstanding as they would be anti-dilutive:

	Year ended December 31,
	2018		2017		2016
Options to purchase ordinary shares		665,219		248,128		49,330
Preferred shares convertible into ordinary shares		—		5,686,663		3,032,457
Unvested restricted stock units		36,924		—		—
Unvested restricted ordinary shares		86,068		189,342		292,620
Warrants		19,890		—		—
Total		808,101		6,124,133		3,374,407

Schedule of Distribution of Total Operating Expenses by Geographical Area

The distribution of total operating expenses by geographical area was as follows:

	Year ended December 31,
Operating expenses	2018		2017		2016
Ireland	$	66,552	$	24,619	$	9,864
U.S.		10,876		5,344		3,495
Total	$	77,428	$	29,963	$	13,359

Schedule of Distribution of Long-Lived Assets by Geographical Area

The distribution of long-lived assets by geographical area was as follows:

Long lived assets	December 31, 2018		December 31, 2017
Ireland	$	4,565	$	2,341
U.S.		245		243
Total	$	4,810	$	2,584

Annual report pursuant to Section 13 and 15(d)

Summary of Significant Accounting Policies (Tables)