Annual report pursuant to Section 13 and 15(d)

Summary of Significant Accounting Policies - Schedule of Distribution of Total Operating Expenses by Geographical Area (Details)

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Summary of Significant Accounting Policies - Schedule of Distribution of Total Operating Expenses by Geographical Area (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Segment Reporting Information [Line Items]      
Operating expenses $ 77,428 $ 29,963 $ 13,359
Ireland      
Segment Reporting Information [Line Items]      
Operating expenses 66,552 24,619 9,864
U.S.      
Segment Reporting Information [Line Items]      
Operating expenses $ 10,876 $ 5,344 $ 3,495