Annual report pursuant to Section 13 and 15(d)

Share-Based Compensation - Summary of Number of Options Outstanding and Weighted-average Exercise Price (Details)

v3.22.1
Share-Based Compensation - Summary of Number of Options Outstanding and Weighted-average Exercise Price (Details) - USD ($)
$ / shares in Units, $ in Thousands
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Compensation Related Costs [Abstract]        
Number of Shares, Options outstanding Beginning Balance 953,377 1,150,270 665,219  
Number of Shares, Granted 15,421,412 64,840 512,778  
Number of Shares, Exercised     (18,232)  
Number of Shares, Forfeited   (134,004) (8,726)  
Number of Shares, Expired (344,979) (127,729) (769)  
Number of Shares, Options outstanding Ending Balance 16,029,810 953,377 1,150,270 665,219
Number of Shares, Exercisable at December 31, 2020 522,450      
Weighted Average Exercise Price, Options outstanding Beginning Balance $ 7.36 $ 7.92 $ 9.31  
Weighted Average Exercise Price, Granted 1.81 1.69 5.94  
Weighted Average Exercise Price, Exercised     3.29  
Weighted Average Exercise Price, Forfeited   8.54 7.43  
Weighted Average Exercise Price, Expired 7.91 8.25 6.77  
Weighted Average Exercise Price, Options outstanding Ending Balance 2.01 $ 7.36 $ 7.92 $ 9.31
Weighted Average Exercise Price, Exercisable at December 31, 2020 $ 7.02      
Weighted Average Remaining Contractual Life in Years, Options outstanding 9 years 5 months 1 day 5 years 4 months 28 days 8 years 7 months 2 days 8 years 11 months 4 days
Weighted Average Remaining Contractual Life in Years, Exercisable at December 31, 2019 6 years 8 months 23 days      
Aggregate Intrinsic Value, Options outstanding   $ 254   $ 395
Aggregate Intrinsic Value, Options outstanding     $ 254