Annual report pursuant to Section 13 and 15(d)

Share-Based Compensation - Additional Information (Details)

v3.22.1
Share-Based Compensation - Additional Information (Details) - USD ($)
12 Months Ended
Nov. 24, 2021
Jun. 23, 2021
Jun. 22, 2021
Jun. 10, 2020
Feb. 14, 2020
Dec. 31, 2018
Dec. 05, 2018
Oct. 14, 2016
Oct. 14, 2015
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Mar. 14, 2018
May 18, 2017
Nov. 18, 2015
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                              
Shares issued in the period                 413,110            
Percentage of remaining restricted ordinary shares vest on monthly basis               0.0278%              
Grant date fair value                             $ 3.14
Share options granted                   15,421,412 64,840 512,778      
Weighted average grant date fair value, options granted                   $ 1.58 $ 1.28 $ 3.80      
Restricted Stock                              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                              
Shares issued in the period                   0 0        
Expense recognized                       $ 260,000      
Employee Stock Options                              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                              
Risk-free interest rate based on estimate of U.S. treasury yield                   7 years          
Employees and Directors                              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                              
Expense recognized                   $ 3,779,000 $ 1,136,000 $ 1,388,000      
Vesting period                   3 years 5 months 26 days 1 year 5 months 19 days 2 years 7 months 9 days      
Share options granted                   15,421,412 64,840 512,778      
Unvested employee options outstanding                   15,507,360 266,666 837,386      
Unamortized compensation expense share options                   $ 21,521,000 $ 970,000 $ 3,342,000      
Restricted Share Units (RSUs)                              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                              
Grant date fair value           $ 13.00       $ 1.28   $ 7.01      
Expense recognized                   $ 960,000 63,000 $ 313,000      
Number of shares, granted/awarded                   1,845,328   31,367      
Unamortized compensation expense                   $ 1,416,000 $ 0        
Remaining average vesting period to recognize unamortized compensation expense                   1 year 10 months 20 days          
Restricted Share Units (RSUs) | Employees and Directors                              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                              
Number of shares, granted/awarded                   1,845,328          
Restricted Share Units (RSUs) | Director                              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                              
Vesting period                   1 year          
Number of shares, granted/awarded                     0 31,367      
Restricted Share Units (RSUs) | Employees                              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                              
Number of shares, granted/awarded                     0        
Performance RSUs                              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                              
Grant date fair value                     $ 2.20 $ 8.21      
Expense recognized                   $ (420,000) $ 1,560,000        
Number of shares, granted/awarded                   0 1,079,000 50,000      
Unamortized compensation expense                     $ 152,000        
Remaining average vesting period to recognize unamortized compensation expense                     2 months 12 days        
Performance RSUs | Employees                              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                              
Number of shares, granted/awarded                     1,079,000 50,000      
Restricted Ordinary Shares, Options and Restricted Share Units and Performance Restricted Share Units                              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                              
Vesting period                   3 years 3 months 25 days 9 months 18 days 2 years 5 months 8 days      
Unamortized compensation expense                   $ 22,937,000 $ 1,122,000 $ 3,639,000      
Tranche One                              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                              
Percentage of awards vested               25.00%              
2015 Plan                              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                              
Number of shares authorized                             223,424
Number of ordinary shares available for issuance                           443,029 219,605
2018 Plan                              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                              
Number of shares authorized                         1,018,459    
Increase in number of ordinary shares available to be granted, percentage         4.00%   4.00%                
Increase in number of ordinary shares available to be granted   19,437,298 15,000,000 2,250,000 594,758 574,081                  
2018 Plan | Restricted Share Units (RSUs) | Employees                              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                              
Vesting period                   2 years          
2021 Inducement Plan                              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                              
Increase in number of ordinary shares available to be granted 5,000,000                            
2015 Plan, 2018 Plan and 2021 Inducement Plan                              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                              
Share options granted                   15,421,412 64,840 512,778      
2015 Plan, 2018 Plan and 2021 Inducement Plan | Employee Stock Options                              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                              
Share option granted term                   10 years          
Vesting period                   4 years          
Vesting rights                   The vesting requirement is conditioned upon a grantee’s continued service with the Company during the vesting period. Once vested, all awards are exercisable from the date of grant until they expire. The option grants are non-transferable. Vested options generally remain exercisable for 90 days subsequent to the termination of the option holder’s service with the Company. In the event of an option holder’s disability or death while employed by or providing service to the Company, the exercisable period extends to twelve months or eighteen months, respectively.          
2015 Plan, 2018 Plan and 2021 Inducement Plan | Restricted Share Units (RSUs)                              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                              
Number of shares, granted/awarded                   1,845,328   31,367      
Two Thousand Twenty One Inducement Plan                              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                              
Share options granted                   1,800,000          
Two Thousand Twenty One Inducement Plan | Restricted Share Units (RSUs)                              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                              
Number of shares, granted/awarded                   500,000          
Two Thousand Twenty One Inducement Plan | Restricted Share Units (RSUs) | Employees                              
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                              
Vesting period                   4 years