Annual report pursuant to Section 13 and 15(d)

Summary of Significant Accounting Policies (Tables)

Summary of Significant Accounting Policies (Tables)

12 Months Ended

Dec. 31, 2021

Schedule of Property and Equipment Depreciated Using the Straight-Line Method Over the Estimated Useful Life of Each Asset

Property and equipment are stated at cost less accumulated depreciation. Property and equipment are depreciated using the straight-line method over the estimated useful life of each asset as follows:

	Estimated Useful Life
Leasehold improvements	Shorter of life of lease or 10 years
Furniture and fixtures	5 years
Laboratory equipment	5 years
Computer equipment	3 years

Schedule of Potentially Dilutive Securities Excluded from Computation of Diluted Weighted-Average Shares Outstanding

The following potentially dilutive securities have been excluded from the computation of diluted weighted-average shares outstanding as they would be anti-dilutive:

	Year ended December 31,
	2021		2020		2019
Options to purchase ordinary shares		16,029,810		953,377		1,150,270
Unvested restricted share units		1,785,328		—		31,367
Unvested performance restricted share units		—		983,000		50,000
Warrants		7,202,878		24,444,292		19,890
Exchangeable Notes		18,260,787		70,725,058		—
Total		43,278,803		97,105,727		1,251,527

Schedule of Distribution of Total Operating Expenses by Geographical Area

The distribution of total operating expenses by geographical area was as follows:

	Year ended December 31,
Operating expenses	2021		2020		2019
Ireland	$	15,926	$	23,423	$	90,792
U.S.		8,554		8,703		11,266
Bermuda		57		—		—
Total	$	24,537	$	32,126	$	102,058

Schedule of Distribution of Long-Lived Assets by Geographical Area

The distribution of long-lived assets by geographical area was as follows:

Long lived assets	December 31, 2021		December 31, 2020
Ireland	$	7,601	$	8,101
U.S.		578		2,971
Total	$	8,179	$	11,072