Annual report pursuant to Section 13 and 15(d)

Share-Based Compensation - Summary of Stock Option Activity (Details)

v3.22.1
Share-Based Compensation - Summary of Stock Option Activity (Details) - shares
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]      
Number of Shares, Options outstanding Beginning Balance 953,377 1,150,270 665,219
Number of Shares, Granted 15,421,412 64,840 512,778
Number of Shares, Exercised     (18,232)
Number of Shares, Forfeited   (134,004) (8,726)
Number of Shares, Expired (344,979) (127,729) (769)
Number of Shares, Options outstanding Ending Balance 16,029,810 953,377 1,150,270
2015 Plan and 2018 Plan      
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]      
Number of Shares, Options outstanding Beginning Balance 953,377 1,150,270 665,219
Number of Shares, Granted 13,621,412 64,840 512,778
Number of Shares, Exercised     (18,232)
Number of Shares, Forfeited   (134,004) (8,726)
Number of Shares, Expired (344,979) (127,729) (769)
Number of Shares, Options outstanding Ending Balance 14,229,810 953,377 1,150,270
Two Thousand Twenty One Inducement Plan      
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]      
Number of Shares, Granted 1,800,000    
Number of Shares, Options outstanding Ending Balance 1,800,000    
2015 Plan, 2018 Plan and 2021 Inducement Plan      
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]      
Number of Shares, Options outstanding Beginning Balance 953,377 1,150,270 665,219
Number of Shares, Granted 15,421,412 64,840 512,778
Number of Shares, Exercised     (18,232)
Number of Shares, Forfeited   (134,004) (8,726)
Number of Shares, Expired (344,979) (127,729) (769)
Number of Shares, Options outstanding Ending Balance 16,029,810 953,377 1,150,270