Quarterly report pursuant to Section 13 or 15(d)

Commitment and Contingencies - Additional Information (Details)

v3.10.0.1
Commitment and Contingencies - Additional Information (Details) - USD ($)
 1 Months Ended
Jun. 30, 2018
Mar. 31, 2018
Apr. 30, 2017
Dec. 31, 2016
Dec. 31, 2017
Jun. 30, 2016
Nov. 18, 2015
Other Commitments [Line Items]              
Purchase obligation $ 2,397,000       $ 599,000 $ 2,923,000  
Pfizer License Agreement | Minimum              
Other Commitments [Line Items]              
Potential future regulatory milestone and sales milestone payments upon achievement of net sales             $ 250,000,000
Pfizer License Agreement | Maximum              
Other Commitments [Line Items]              
Potential future regulatory milestone and sales milestone payments upon achievement of net sales             $ 1,000,000,000
Supplemental Agreement              
Other Commitments [Line Items]              
Purchase obligation $ 2,397,000            
Commercial Unit Lease Agreement | Dublin              
Other Commitments [Line Items]              
Operating lease agreement, term of contract 20 years            
Operating lease agreement, break option term of contract 10 years            
Operating lease agreement, commencement period 2018-06            
Annual lease payments $ 321,000            
Operating lease agreement, rental review 5 years            
Security deposit $ 818,000            
Office Space Lease Agreement | Dublin              
Other Commitments [Line Items]              
Operating lease agreement, term of contract       10 years      
Annual lease payments       $ 375,000      
Operating lease agreement, renewal term       5 years      
Operating lease agreement, commencement date       Dec. 01, 2016      
Operating lease agreement, expiration date       Dec. 01, 2026      
Operating lease agreement, review period       2022-12      
Office Space Lease Agreement | Dublin | Other Assets              
Other Commitments [Line Items]              
Security deposit       $ 338,000      
Office Space Lease Agreement | Chicago              
Other Commitments [Line Items]              
Operating lease agreement, term of contract   5 years          
Operating lease agreement, commencement period   2018-06          
Annual lease payments   $ 258,000          
Security deposit   $ 120,000          
Operating lease agreement, renewal term   5 years          
Office Space Lease Agreement | Connecticut              
Other Commitments [Line Items]              
Operating lease agreement, term of contract     5 years        
Operating lease agreement, commencement period     2017-07        
Annual lease payments     $ 131,000        
Operating lease agreement, renewal term     3 years        
Office Space Lease Agreement | Connecticut | Other Assets              
Other Commitments [Line Items]              
Security deposit     $ 17,000