Summary of Significant Accounting Policies (Tables)

Summary of Significant Accounting Policies (Tables)

6 Months Ended

Jun. 30, 2018

Schedule of Potentially Dilutive Securities Excluded from Computation of Diluted Weighted-Average Shares Outstanding

The following potentially dilutive securities have been excluded from the computation of diluted weighted-average shares outstanding as they would be anti-dilutive:

	Six months ended
	June 30, 2018		June 30, 2017
Options to purchase ordinary shares		696,112		66,832
Preferred shares convertible into ordinary shares		—		5,686,667
Unvested restricted ordinary shares		143,076		246,282
Unvested restricted stock units		36,924		—
Warrants		19,890		—
Total		896,002		5,999,781

Schedule of Distribution of Total Operating Expenses by Geographical Area

The distribution of total operating expenses by geographical area was as follows:

	Three months ended June 30,				Six months ended June 30,
Operating expenses	2018		2017		2018		2017
Ireland	$	12,811	$	5,205	$	22,775	$	9,674
U.S.		2,800		1,208		5,230		2,281
Total	$	15,611	$	6,413	$	28,005	$	11,955

Schedule of Distribution of Long-Lived Assets by Geographical Area

The distribution of long-lived assets by geographical area was as follows:

Long lived assets	June 30, 2018		December 31, 2017
Ireland	$	3,388	$	2,341
U.S.		369		243
Total	$	3,757	$	2,584

Quarterly report pursuant to Section 13 or 15(d)

Summary of Significant Accounting Policies (Tables)