Annual report pursuant to Section 13 and 15(d)

Share-Based Compensation - Additional Information (Details)

Share-Based Compensation - Additional Information (Details) - USD ($)								12 Months Ended
	Jul. 07, 2022	Jun. 22, 2021	Jun. 10, 2020	Feb. 14, 2020	Dec. 31, 2018	Dec. 05, 2018	Nov. 18, 2015	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021	Nov. 24, 2021	Jun. 23, 2021	Mar. 14, 2018
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of Shares, Cancelled										(906,800)
Cancellation Of Share Option										$ 17,350,000
Share options granted									857,500	197,085
Weighted average grant date fair value, options granted									$ 0.8	$ 2.39
Employee Stock Option
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Risk-free interest rate based on estimate of U.S. treasury yield								7 years
Employees and Directors
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Expense recognized								$ 368,000	$ 468,000	$ 3,580,000
Vesting period								1 year 2 months 26 days	2 years 1 month 2 days	1 year 4 months 28 days
Share options granted								0	857,500	197,085
Unvested employee options outstanding								307,908	930,010	296,199
Unamortized compensation expense share options								$ 268,000	$ 1,000,000	$ 929,000
Restricted Share Units (RSUs)
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Grant date fair value									$ 7.26	$ 9.87	$ 19.16
Expense recognized									$ 316,000	$ 1,178,000
Number of shares, granted/awarded										66,398
Unamortized compensation expense								0	$ 116,000	$ 434,000
Stock-based compensation expense, expected weighted average period for recognition									1 year 11 months 1 day	10 months 17 days
Benefit recognized related to share based compensation								$ 5,000
Restricted Share Units (RSUs) \| Employees and Directors
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of shares, granted/awarded								0	0	66,398
Restricted Share Units (RSUs) \| Director
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Vesting period								1 year
Restricted Ordinary Shares, Options and Restricted Share Units and Performance Restricted Share Units
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Vesting period								1 year 2 months 26 days	2 years 25 days	1 year 3 months 10 days
Unamortized compensation expense								$ 268,000	$ 1,116,000	$ 1,363,000
2015 Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of shares authorized							14,895
Number of ordinary shares available for issuance							29,535
Increase in number of ordinary shares available for issuance							14,640
2018 Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of shares authorized													1,295,819	67,897
Increase in number of ordinary shares available to be granted, percentage				4.00%		4.00%
Increase in number of ordinary shares available to be granted		1,000,000	150,000	39,650	38,272
2018 Plan \| Restricted Share Units (RSUs) \| Employees
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Vesting period								2 years
2021 Inducement Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of shares authorized												333,333
2021 Inducement Plan \| Restricted Share Units (RSUs) \| Employees
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Vesting period								4 years
2015 Plan, 2018 Plan and 2021 Inducement Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of Shares, Cancelled										(906,800)
Share options granted									857,500	197,085
2015 Plan, 2018 Plan and 2021 Inducement Plan \| Employee Stock Option
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share option granted term								10 years
Vesting rights								The vesting requirement is conditioned upon a grantee’s continued service with the Company during the vesting period. Once vested, all awards are exercisable from the date of grant until they expire. The option grants are non-transferable. Vested options generally remain exercisable for 90 days subsequent to the termination of the option holder’s service with the Company. In the event of an option holder’s disability or death while employed by or providing service to the Company, the exercisable period extends to twelve months or eighteen months, respectively.
2015 Plan, 2018 Plan and 2021 Inducement Plan \| Employee Stock Option \| Maximum
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Vesting period								4 years
2015 Plan, 2018 Plan and 2021 Inducement Plan \| Employee Stock Option \| Minimum
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Vesting period								3 years
2015 Plan, 2018 Plan and 2021 Inducement Plan \| Restricted Share Units (RSUs)
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of shares, granted/awarded										66,398
Two Thousand Twenty One Inducement Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share options granted									2,500	6,332
Amended And Restated 2018 Equity Incentive Plan [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of Shares, Cancelled	906,800
Amended And Restated 2018 Equity Incentive Plan [Member] \| Employee Stock Option
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Cancellation Of Share Option										$ 17,350,000