Annual report pursuant to Section 13 and 15(d)

Shareholders' Equity / (Deficit) - Additional Information (Details)

Shareholders' Equity / (Deficit) - Additional Information (Details)															1 Months Ended	12 Months Ended			47 Months Ended
	Dec. 12, 2024 USD ($)	Aug. 09, 2024 USD ($) $ / shares shares	Oct. 17, 2022 USD ($)	Oct. 07, 2022 USD ($)	Feb. 12, 2021 $ / shares shares	Feb. 10, 2021 USD ($) $ / shares shares	Feb. 09, 2021 USD ($) $ / shares shares	Feb. 08, 2021 $ / shares shares	Feb. 03, 2021 $ / shares shares	Oct. 31, 2020 $ / shares shares	Oct. 27, 2020 $ / shares shares	Jul. 02, 2020 $ / shares shares	Jun. 05, 2020 $ / shares shares	Jun. 03, 2020 $ / shares shares	Jun. 30, 2020 $ / shares shares	Dec. 31, 2024 USD ($) Vote $ / shares shares	Dec. 31, 2023 USD ($) $ / shares shares	Dec. 31, 2022 USD ($)	Dec. 31, 2024 USD ($) $ / shares shares	May 03, 2023 $ / shares shares	Apr. 27, 2018 $ / shares shares	Apr. 17, 2018 shares
Class Of Stock [Line Items]
Increase to authorized ordinary shares																				60,000,000
Ordinary shares, par value \| $ / shares																$ 0.01	$ 0.01		$ 0.01	$ 0.01
Ordinary shares, shares authorized																80,000,000	80,000,000		80,000,000
Number of vote per common share \| Vote																1
Common stock rights and preferences																There are no redemption or sinking fund provisions with respect to the authorized ordinary shares.
Authorized amount for sale of stock \| $			$ 100,000,000
Ordinary shares, shares issued																31,534,233	13,499,003		31,534,233
Proceeds from registered direct offerings, net of transaction costs \| $																$ 26,691,000	$ 1,034,000	$ 433,000
Aggregate principal amount of exchangeable notes \| $																			$ 40,691,000
Undesignated preferred shares, par value \| $ / shares																$ 0.01	$ 0.01		$ 0.01
Undesignated preferred shares, authorized																100,000,000	100,000,000		100,000,000
Undesignated preferred shares issued																0	0		0
Sales Agreement With H.C. Wainwright
Class Of Stock [Line Items]
Number of ordinary shares sold																10,327,787	639,825
Offering price per share \| $ / shares																$ 1.94	$ 1.68		$ 1.94
Proceeds from registered direct offerings, net of transaction costs \| $																$ 19,405,000	$ 1,034,000
Maximum \| Sales Agreement With H.C. Wainwright
Class Of Stock [Line Items]
May offer and sell ordinary shares for aggregate gross sales proceeds \| $				$ 16,000,000
May offer and sell ordinary shares for additional aggregate offering price \| $	$ 25,000,000
2024 Rights Offering
Class Of Stock [Line Items]
Number of units sold		6,121,965
Subscription price per whole unit \| $ / shares		$ 1.21
Aggregate gross proceeds from rights offering \| $		$ 7,400,000
Aggregate net proceeds from rights offering \| $		$ 5,400,000
Warrants to purchase ordinary shares, exercise price \| $ / shares		$ 1.21
Private Placement \| Securities Purchase Agreement
Class Of Stock [Line Items]
Number of warrants to purchase ordinary shares													13,868
Warrants to purchase ordinary shares, exercise price \| $ / shares													$ 31.5465	$ 24.3
Warrants expiry date													Jun. 03, 2025	Dec. 05, 2025
Percentage of ordinary shares issued to purchase warrants													7.00%
Private Placement \| Securities Purchase Agreement \| Maximum
Class Of Stock [Line Items]
Number of warrants to purchase ordinary shares														99,057
Private Placement \| June 30 SPA
Class Of Stock [Line Items]
Number of warrants to purchase ordinary shares												15,739
Warrants exercised																84,317			84,317
Warrants to purchase ordinary shares, exercise price \| $ / shares												$ 27.7965			$ 21.3
Warrants expiry date												Jun. 30, 2025			Jan. 02, 2026
Percentage of ordinary shares issued to purchase warrants												7.00%
Proceeds from exercise of warrants related to registered direct offering \| $																$ 1,796,000
Private Placement \| June 30 SPA \| Maximum
Class Of Stock [Line Items]
Number of warrants to purchase ordinary shares															112,422
October Offering
Class Of Stock [Line Items]
Proceeds from registered direct offerings, net of transaction costs \| $																$ 13,885,000
Number of warrants to purchase ordinary shares										125,641
Number of warrants exercised for ordinary shares																1,392,701			1,392,701
Warrants to purchase ordinary shares, exercise price \| $ / shares										$ 12.1875	$ 9.75
Warrants expiry date										Oct. 22, 2025	Oct. 27, 2025
Percentage of ordinary shares issued to purchase warrants										7.00%
October Offering \| Maximum
Class Of Stock [Line Items]
Number of warrants to purchase ordinary shares											1,346,153
February Underwritten Offering
Class Of Stock [Line Items]
Ordinary shares, shares issued						2,666,666
Offering closing date						Feb. 10, 2021		Feb. 08, 2021
Proceeds from registered direct offerings, net of transaction costs \| $																$ 546,000
Warrants exercised																25,333			25,333
Warrants to purchase ordinary shares, exercise price \| $ / shares						$ 21.5625		$ 21.5625
Warrants expiry date						Feb. 03, 2026		Feb. 03, 2026
Percentage of ordinary shares issued to purchase warrants						7.00%		7.00%
February Underwritten Offering \| Underwriting Agreement
Class Of Stock [Line Items]
Ordinary shares, par value \| $ / shares									$ 0.01
Ordinary shares, shares issued									2,318,840
Offering closing date									Feb. 08, 2021
February Underwritten Offering \| Pursuant to the Underwriting Agreement
Class Of Stock [Line Items]
Additional ordinary shares that can be purchased by underwriter						347,826
Aggregate gross proceeds from ordinary shares \| $						$ 46,000,000
Net proceeds from registered direct offerings, net of transaction costs \| $						$ 42,119,000
February Underwritten Offering \| Maximum
Class Of Stock [Line Items]
Number of warrants to purchase ordinary shares						24,347		162,318
February 2021 Underwritten Offering \| Underwriting Agreement
Class Of Stock [Line Items]
Offering price per share \| $ / shares									$ 17.25
February Registered Direct Offering
Class Of Stock [Line Items]
Ordinary shares, par value \| $ / shares							$ 0.01
Ordinary shares, shares issued							1,166,666
Offering price per share \| $ / shares							$ 30
Offering closing date					Feb. 12, 2021		Feb. 12, 2021
Aggregate gross proceeds from ordinary shares \| $							$ 35,000,000
Net proceeds from registered direct offerings, net of transaction costs \| $							$ 32,235,000
Number of warrants to purchase ordinary shares					81,666
Warrants to purchase ordinary shares, exercise price \| $ / shares					$ 37.5
Warrants expiry date					Feb. 09, 2026
Percentage of ordinary shares issued to purchase warrants					7.00%
Warrants to Purchase 19,890 Ordinary Shares \| Silicon Valley Bank and Life Sciences Fund II LLC
Class Of Stock [Line Items]
Warrants expiry date																Apr. 27, 2028
Series B Convertible Preferred Shares \| Silicon Valley Bank and Life Sciences Fund II LLC
Class Of Stock [Line Items]
Number of warrants to purchase ordinary shares																					19,890	19,890
Warrants to purchase ordinary shares, exercise price \| $ / shares																$ 282.75			$ 282.75		$ 282.75
Undesignated Preferred Shares
Class Of Stock [Line Items]
Undesignated preferred shares, par value \| $ / shares																$ 0.01			$ 0.01
Undesignated preferred shares, authorized																100,000,000			100,000,000
Undesignated preferred shares issued																0	0		0
Ordinary Shares \| Silicon Valley Bank and Life Sciences Fund II LLC
Class Of Stock [Line Items]
Number of warrants to purchase ordinary shares																1,326			1,326		1,326
1-Year Warrant \| 2024 Rights Offering
Class Of Stock [Line Items]
Number of shares that can be purchased with each warrant		0.5
Proceeds from registered direct offerings, net of transaction costs \| $																$ 1,030,000
Number of warrants to purchase ordinary shares		3,060,982
Warrants exercised																850,998			850,998
Warrants to purchase ordinary shares, exercise price \| $ / shares		$ 1.21														$ 1.21			$ 1.21
5-Year Warrants \| 2024 Rights Offering
Class Of Stock [Line Items]
Proceeds from registered direct offerings, net of transaction costs \| $																$ 783,000
Number of warrants to purchase ordinary shares		6,121,965
Warrants exercised																647,147			647,147
Warrants to purchase ordinary shares, exercise price \| $ / shares		$ 1.21														$ 1.21			$ 1.21
Exchangeable Notes
Class Of Stock [Line Items]
Ordinary shares, shares issued																3,760,155			3,760,155
Aggregate principal amount of exchangeable notes \| $																			$ 40,691,000
Aggregate principal amount \| $																$ 11,117,000			11,117,000
Exchangeable Notes \| Private Placement
Class Of Stock [Line Items]
Aggregate principal amount of exchangeable notes \| $																			$ 40,691,000