Annual report pursuant to Section 13 and 15(d)

Nature of Operations and Basis of Presentation - Additional Information (Details)

Nature of Operations and Basis of Presentation - Additional Information (Details)					12 Months Ended
	Dec. 10, 2024 USD ($)	Aug. 09, 2024 USD ($) $ / shares shares	Oct. 07, 2022 USD ($) $ / shares	Jan. 21, 2020 USD ($) Debtinstrument	Dec. 31, 2024 USD ($) $ / shares	Dec. 31, 2023 USD ($) $ / shares	Dec. 31, 2022 USD ($)	May 03, 2023 $ / shares	Oct. 17, 2022 USD ($)	Sep. 08, 2020 USD ($)
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Net losses					$ 24,774,000	$ 38,371,000	$ 44,434,000
Accumulated deficit					486,072,000	461,298,000
Cash and cash equivalents					$ 24,125,000	$ 6,071,000
Ordinary shares, par value \| $ / shares					$ 0.01	$ 0.01		$ 0.01
Maximum
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Value of shares and securities may offer and sell									$ 100,000,000
Sales Agreement with H.C. Wainwright & Co., L.L.C
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Ordinary shares, par value \| $ / shares			$ 0.01
Sales Agreement with H.C. Wainwright & Co., L.L.C \| Maximum
Organization Consolidation And Presentation Of Financial Statements [Line Items]
May offer and sell ordinary shares for aggregate gross sales proceeds			$ 16,000,000
May offer and sell ordinary shares for additional aggregate offering price	$ 25,000,000
2024 Rights Offering
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Number of units sold \| shares		6,121,965
Subscription price per whole unit \| $ / shares		$ 1.21
Warrants to purchase ordinary shares, exercise price \| $ / shares		$ 1.21
Aggregate net proceeds from rights offering		$ 5,400,000
2024 Rights Offering \| 1-Year Warrant
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Number of shares that can be purchased with each warrant \| shares		0.5
Warrants to purchase ordinary shares, exercise price \| $ / shares		$ 1.21			1.21
2024 Rights Offering \| 5-Year Warrants
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Warrants to purchase ordinary shares, exercise price \| $ / shares		$ 1.21			$ 1.21
2025 Exchangeable Notes
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Aggregate principal amount				$ 9,891,000	$ 11,117,000
2025 Exchangeable Notes \| Private Placement and Rights Offering
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Aggregate principal amount										$ 51,800,000
Debt instrument interest rate				6.50%
2025 Exchangeable Notes \| Private Placement
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Aggregate principal amount				$ 51,588,000
Debt instrument price per unit				1,000
RLNs \| Private Placement and Rights Offering
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Aggregate principal amount				100,000						$ 500
RLNs \| Private Placement
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Aggregate principal amount				$ 103,000
Number of debt instruments within each notes \| Debtinstrument				50