Quarterly report pursuant to Section 13 or 15(d)

Basis of Presentation - Additional Information (Details)

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Basis of Presentation - Additional Information (Details) - USD ($)
 3 Months Ended 12 Months Ended
Oct. 07, 2022
Mar. 31, 2024
Mar. 31, 2023
Dec. 31, 2023
May 31, 2023
May 03, 2023
Oct. 17, 2022
Sep. 08, 2020
Jan. 21, 2020
Organization Consolidation And Presentation Of Financial Statements [Line Items]                  
Net losses   $ 7,101,000 $ 9,889,000 $ 38,371,000          
Accumulated deficit   468,399,000   461,298,000          
Cash and cash equivalents   $ 7,389,000   $ 6,071,000          
Ordinary shares, par value   $ 0.01 $ 0.01 $ 0.01   $ 0.01      
Issuance of ordinary shares   1,700,000              
Additional ordinary shares with preemptive rights         60,000,000        
Maximum                  
Organization Consolidation And Presentation Of Financial Statements [Line Items]                  
Value of shares and securities may offer and sell             $ 100,000,000    
Sales Agreement with H.C. Wainwright & Co., L.L.C                  
Organization Consolidation And Presentation Of Financial Statements [Line Items]                  
Ordinary shares, par value $ 0.01                
Sales Agreement with H.C. Wainwright & Co., L.L.C | Maximum                  
Organization Consolidation And Presentation Of Financial Statements [Line Items]                  
May offer and sell ordinary shares for aggregate gross sales proceeds $ 16,000,000                
2025 Exchangeable Notes                  
Organization Consolidation And Presentation Of Financial Statements [Line Items]                  
Aggregate principal amount   $ 11,117,000             $ 9,891,000
2025 Exchangeable Notes | Private Placement and Rights Offering                  
Organization Consolidation And Presentation Of Financial Statements [Line Items]                  
Aggregate principal amount               $ 51,800,000  
Debt instrument interest rate                 6.50%
RLNs | Private Placement and Rights Offering                  
Organization Consolidation And Presentation Of Financial Statements [Line Items]                  
Aggregate principal amount               $ 500 $ 100,000