Quarterly report pursuant to Section 13 or 15(d)

Shareholders' Equity - Additional Information (Details)

Shareholders' Equity - Additional Information (Details)											1 Months Ended	3 Months Ended	26 Months Ended
Shareholders' Equity - Additional Information (Details)	Oct. 17, 2022 USD ($)	Oct. 07, 2022 USD ($) $ / shares	Feb. 12, 2021 $ / shares shares	Feb. 10, 2021 $ / shares shares	Feb. 08, 2021 $ / shares shares	Oct. 31, 2020 $ / shares shares	Oct. 27, 2020 $ / shares shares	Jul. 02, 2020 $ / shares shares	Jun. 05, 2020 $ / shares shares	Jun. 03, 2020 $ / shares shares	Jun. 30, 2020 $ / shares shares	Mar. 31, 2023 USD ($) Vote $ / shares shares	Mar. 31, 2023 USD ($) $ / shares shares	Dec. 31, 2022 $ / shares shares	Aug. 17, 2022 $ / shares	Mar. 31, 2022 $ / shares	Jan. 28, 2021 $ / shares shares	Apr. 27, 2018 $ / shares shares
Class Of Stock [Line Items]
Ordinary shares, shares issued												12,805,833	12,805,833	12,598,641
Ordinary shares, par value \| $ / shares												$ 0.01	$ 0.01	$ 0.01	$ 0.01	$ 0.01	$ 0.01
Proceeds from warrants being exercised \| $												$ 546,000
Warrants exercised												25,333	25,333
Ordinary shares, shares authorized												20,000,000	20,000,000	20,000,000
Increase to authorized ordinary shares																	10,000,000
Number of vote per common share \| Vote												1
Common stock rights and preferences												The holders of ordinary shares currently have no preemptive or other subscription rights, and there are no redemption or sinking fund provisions with respect to such shares.
Authorized amount for sale of stock \| $	$ 100,000,000.0
Undesignated preferred shares, par value \| $ / shares												$ 0.01	$ 0.01	$ 0.01
Undesignated preferred shares, authorized												100,000,000	100,000,000	100,000,000
Undesignated preferred shares issued												0	0	0
Undesignated Preferred Shares
Class Of Stock [Line Items]
Undesignated preferred shares, par value \| $ / shares												$ 0.01	$ 0.01
Undesignated preferred shares, authorized												100,000,000	100,000,000
Designated Preferred Shares
Class Of Stock [Line Items]
Undesignated preferred shares issued												0	0	0
Silicon Valley Bank and Life Sciences Fund II LLC \| Series B Convertible Preferred Shares
Class Of Stock [Line Items]
Warrants to purchase convertible preferred shares/ordinary shares												19,890	19,890					19,890
Warrants to purchase ordinary shares, exercise price \| $ / shares												$ 282.75	$ 282.75					$ 282.75
Exchangeable Notes
Class Of Stock [Line Items]
Ordinary shares, shares issued												3,592,555	3,592,555
Aggregate principal amount of exchangeable notes \| $													$ 39,201,000
Aggregate principal amount \| $												$ 12,607,000	$ 12,607,000
Ordinary Shares
Class Of Stock [Line Items]
Warrants to purchase convertible preferred shares/ordinary shares												1,326	1,326					1,326
Sales Agreement With H.C. Wainwright
Class Of Stock [Line Items]
Ordinary shares, par value \| $ / shares		$ 0.01
Sales Agreement With H.C. Wainwright \| Maximum
Class Of Stock [Line Items]
May offer and sell ordinary shares for aggregate gross sales proceeds \| $		$ 16,000,000.0
October Offering
Class Of Stock [Line Items]
Proceeds from warrants being exercised \| $												$ 13,885,000
Warrants exercised												1,392,701	1,392,701
Warrants to purchase convertible preferred shares/ordinary shares						125,641
Warrants to purchase ordinary shares, exercise price \| $ / shares						$ 12.1875	$ 9.75
Warrants expiry date						Oct. 22, 2025	Oct. 27, 2025
Percentage of ordinary shares issued to purchase warrants						7.00%
October Offering \| Maximum
Class Of Stock [Line Items]
Warrants to purchase convertible preferred shares/ordinary shares							1,346,153
February Underwritten Offering
Class Of Stock [Line Items]
Warrants to purchase ordinary shares, exercise price \| $ / shares				$ 21.5625	$ 21.5625
Offering closing date				Feb. 10, 2021	Feb. 08, 2021
Additional ordinary shares that can be purchased by underwriter				347,826
Warrants expiry date				Feb. 03, 2026	Feb. 03, 2026
Percentage of ordinary shares issued to purchase warrants				7.00%	7.00%
February Underwritten Offering \| Maximum
Class Of Stock [Line Items]
Warrants to purchase convertible preferred shares/ordinary shares				24,347	162,318
Private Placement \| Securities Purchase Agreement
Class Of Stock [Line Items]
Warrants to purchase convertible preferred shares/ordinary shares									13,868
Warrants to purchase ordinary shares, exercise price \| $ / shares									$ 31.5465	$ 24.30
Warrants expiry date										Dec. 05, 2025
Percentage of ordinary shares issued to purchase warrants									7.00%
Private Placement \| Securities Purchase Agreement \| Maximum
Class Of Stock [Line Items]
Warrants to purchase convertible preferred shares/ordinary shares										99,057
Private Placement \| June 30 SPA
Class Of Stock [Line Items]
Proceeds from warrants being exercised \| $												$ 1,796,000
Warrants exercised												84,317	84,317
Warrants to purchase convertible preferred shares/ordinary shares								15,739
Warrants to purchase ordinary shares, exercise price \| $ / shares								$ 27.7965			$ 21.30
Warrants expiry date								Jun. 30, 2025			Jan. 02, 2026
Percentage of ordinary shares issued to purchase warrants								7.00%
Private Placement \| June 30 SPA \| Maximum
Class Of Stock [Line Items]
Warrants to purchase convertible preferred shares/ordinary shares											112,422
Private Placement \| Exchangeable Notes
Class Of Stock [Line Items]
Aggregate principal amount of exchangeable notes \| $												$ 39,201,000
At-the-market agreement
Class Of Stock [Line Items]
Offering price per share \| $ / shares												$ 1.32	$ 1.32
Proceeds from registered direct offerings, net of transaction costs \| $												$ 200,000
Number of ordinary shares sold												184,094
Warrants to Purchase 19,890 Ordinary Shares
Class Of Stock [Line Items]
Warrants expiry date												Apr. 27, 2028
February Registered Direct Offering
Class Of Stock [Line Items]
Warrants to purchase ordinary shares, exercise price \| $ / shares			$ 37.50
Offering closing date			Feb. 12, 2021
Warrants expiry date			Feb. 09, 2026
Percentage of ordinary shares issued to purchase warrants			7.00%
February Registered Direct Offering \| Maximum
Class Of Stock [Line Items]
Warrants to purchase convertible preferred shares/ordinary shares			81,666