Quarterly report pursuant to Section 13 or 15(d)

Shareholders' Equity - Additional Information (Details)

Shareholders' Equity - Additional Information (Details) $ / shares in Units, $ in Thousands											1 Months Ended	9 Months Ended	20 Months Ended
	Feb. 12, 2021 $ / shares shares	Feb. 10, 2021 USD ($) $ / shares shares	Feb. 09, 2021 USD ($) $ / shares shares	Feb. 08, 2021 $ / shares shares	Feb. 03, 2021 $ / shares shares	Oct. 31, 2020 $ / shares shares	Oct. 27, 2020 $ / shares shares	Jul. 02, 2020 $ / shares shares	Jun. 05, 2020 $ / shares shares	Jun. 03, 2020 $ / shares shares	Jun. 30, 2020 $ / shares shares	Sep. 30, 2022 USD ($) Vote $ / shares shares	Sep. 30, 2022 USD ($) $ / shares shares	Aug. 17, 2022 $ / shares	Dec. 31, 2021 $ / shares shares	Jan. 28, 2021 $ / shares shares	Apr. 27, 2018 $ / shares shares
Class Of Stock [Line Items]
Ordinary shares, shares issued												12,233,374	12,233,374		12,185,018
Ordinary shares, par value \| $ / shares												$ 0.01	$ 0.01	$ 0.01	$ 0.01	$ 0.01
Proceeds from warrants connected to registered direct offerings \| $												$ 546
Number of warrants to purchase ordinary shares												25,333	25,333
Ordinary shares, shares authorized												20,000,000	20,000,000		20,000,000
Increase to authorized ordinary shares																10,000,000
Number of vote per common share \| Vote												1
Common stock rights and preferences												The holders of ordinary shares currently have no preemptive or other subscription rights, and there are no redemption or sinking fund provisions with respect to such shares
Undesignated preferred shares, par value \| $ / shares												$ 0.01	$ 0.01		$ 0.01
Undesignated preferred shares, authorized												100,000,000	100,000,000		100,000,000
Undesignated preferred shares issued												0	0		0
Undesignated Preferred Shares
Class Of Stock [Line Items]
Undesignated preferred shares, par value \| $ / shares												$ 0.01	$ 0.01
Undesignated preferred shares, authorized												100,000,000	100,000,000
Designated Preferred Shares
Class Of Stock [Line Items]
Undesignated preferred shares issued												0	0		0
Silicon Valley Bank and Life Sciences Fund II LLC \| Series B Convertible Preferred Shares
Class Of Stock [Line Items]
Number of warrants to purchase ordinary shares												19,890	19,890				19,890
Warrants to purchase ordinary shares, exercise price \| $ / shares												$ 282.75	$ 282.75				$ 282.75
Exchangeable Notes
Class Of Stock [Line Items]
Ordinary shares, shares issued												3,592,555	3,592,555
Aggregate principal amount of exchangeable notes \| $													$ 39,201
Aggregate principal amount \| $												$ 12,607	$ 12,607
Ordinary Shares
Class Of Stock [Line Items]
Number of warrants to purchase ordinary shares												1,326	1,326				1,326
October Offering
Class Of Stock [Line Items]
Ordinary shares, par value \| $ / shares												$ 0.01	$ 0.01
Proceeds from registered direct offerings, net of transaction costs \| $												$ 13,885
Number of warrants to purchase ordinary shares						125,641						1,392,701	1,392,701
Warrants to purchase ordinary shares, exercise price \| $ / shares						$ 12.1875	$ 9.75
Warrants expiry date						Oct. 22, 2025	Oct. 27, 2025
Percentage of ordinary shares issued to purchase warrants						7.00%
October Offering \| Maximum
Class Of Stock [Line Items]
Number of warrants to purchase ordinary shares							1,346,153
February Underwritten Offering
Class Of Stock [Line Items]
Warrants to purchase ordinary shares, exercise price \| $ / shares		$ 21.5625		$ 21.5625
Offering closing date		Feb. 10, 2021		Feb. 08, 2021
Additional ordinary shares that can be purchased by underwriter		347,826
Warrants expiry date		Feb. 03, 2026		Feb. 03, 2026
Percentage of ordinary shares issued to purchase warrants		7.00%		7.00%
February Underwritten Offering \| Maximum
Class Of Stock [Line Items]
Number of warrants to purchase ordinary shares		24,347		162,318
February Underwritten Offering \| Underwriting Agreement
Class Of Stock [Line Items]
Ordinary shares, shares issued					2,318,840
Ordinary shares, par value \| $ / shares					$ 0.01
Offering closing date					Feb. 08, 2021
February Underwritten Offering \| Pursuant to the Underwriting Agreement
Class Of Stock [Line Items]
Ordinary shares, shares issued		2,666,666
Aggregate gross proceeds from ordinary shares \| $		$ 46,000
Proceeds from registered direct offerings, net of transaction costs \| $		$ 42,119
Additional ordinary shares that can be purchased by underwriter		347,826
February 2021 Underwritten Offering \| Underwriting Agreement
Class Of Stock [Line Items]
Offering price per share \| $ / shares					$ 17.25
Private Placement \| Securities Purchase Agreement
Class Of Stock [Line Items]
Number of warrants to purchase ordinary shares									13,868
Warrants to purchase ordinary shares, exercise price \| $ / shares									$ 31.5465	$ 24.30
Warrants expiry date										Dec. 05, 2025
Percentage of ordinary shares issued to purchase warrants									7.00%
Private Placement \| Securities Purchase Agreement \| Maximum
Class Of Stock [Line Items]
Number of warrants to purchase ordinary shares										99,057
Private Placement \| June 30 SPA
Class Of Stock [Line Items]
Proceeds from exercise of warrants related to registered direct offering \| $												$ 1,796
Number of warrants to purchase ordinary shares								15,739				84,317	84,317
Warrants to purchase ordinary shares, exercise price \| $ / shares								$ 27.7965			$ 21.30
Warrants expiry date								Jun. 30, 2025			Jan. 02, 2026
Percentage of ordinary shares issued to purchase warrants								7.00%
Private Placement \| June 30 SPA \| Maximum
Class Of Stock [Line Items]
Number of warrants to purchase ordinary shares											112,422
Private Placement \| Exchangeable Notes
Class Of Stock [Line Items]
Aggregate principal amount of exchangeable notes \| $													$ 39,201
Warrants to Purchase 19,890 Ordinary Shares
Class Of Stock [Line Items]
Warrants expiry date												Apr. 27, 2028
February Registered Direct Offering
Class Of Stock [Line Items]
Ordinary shares, shares issued			1,166,666
Ordinary shares, par value \| $ / shares			$ 0.01
Offering price per share \| $ / shares			$ 0.00
Aggregate gross proceeds from ordinary shares \| $			$ 35,000
Proceeds from registered direct offerings, net of transaction costs \| $			$ 32,235
Warrants to purchase ordinary shares, exercise price \| $ / shares	$ 37.50
Offering closing date	Feb. 12, 2021		Feb. 12, 2021
Warrants expiry date	Feb. 09, 2026
Percentage of ordinary shares issued to purchase warrants	7.00%
February Registered Direct Offering \| Maximum
Class Of Stock [Line Items]
Number of warrants to purchase ordinary shares	81,666