Quarterly report pursuant to Section 13 or 15(d)

Summary of Significant Accounting Policies (Tables)

Summary of Significant Accounting Policies (Tables)

9 Months Ended

Sep. 30, 2021

Schedule of Potentially Dilutive Securities Excluded from Computation of Diluted Weighted-Average Shares Outstanding

For the periods presented, the following ordinary shares underlying the options, unvested restricted share units, unvested performance restricted share units, warrants and the Exchangeable Notes have been excluded from the calculation because they would be anti-dilutive.

	Three months ended				Nine Months Ended
	September 30, 2021		September 30, 2020		September 30, 2021		September 30, 2020
Options to purchase ordinary shares		—		1,147,490		14,271,397		1,147,490
Unvested restricted share units		—		—		1,285,328		—
Unvested performance restricted share units		—		1,042,000		26,000		1,042,000
Warrants		—		3,636,229		7,202,878		3,636,229
Exchangeable Notes		—		69,642,254		17,997,296		69,642,254
Total		—		75,467,973		40,782,899		75,467,973

Schedule of Distribution of Total Operating Expenses by Geographical Area

The distribution of total operating expenses by geographical area was as follows:

	Three Months Ended September 30,				Nine Months Ended September 30,
Operating expenses	2021		2020		2021		2020
Ireland	$	3,056	$	4,859	$	11,166	$	19,931
U.S.		1,817		1,476		6,495		7,551
Bermuda		1		—		47		—
Total	$	4,874	$	6,335	$	17,708	$	27,482

Schedule of Distribution of Long-Lived Assets by Geographical Area

The distribution of long-lived assets by geographical area was as follows:

Long-lived assets	September 30, 2021		December 31, 2020
Ireland	$	7,513	$	8,101
U.S.		632		2,971
Total	$	8,145	$	11,072