Summary of Significant Accounting Policies (Tables)

Summary of Significant Accounting Policies (Tables)

9 Months Ended

Sep. 30, 2018

Schedule of Potentially Dilutive Securities Excluded from Computation of Diluted Weighted-Average Shares Outstanding

The following potentially dilutive securities have been excluded from the computation of diluted weighted-average shares outstanding as they would be anti-dilutive:

	Nine Months Ended
	September 30, 2018		September 30, 2017
Options to purchase ordinary shares		698,114		237,626
Preferred shares convertible into ordinary shares		—		5,686,667
Unvested restricted stock units		36,924		—
Unvested restricted ordinary shares		107,165		210,372
Warrants		19,890		—
Total		862,093		6,134,665

Schedule of Distribution of Total Operating Expenses by Geographical Area

The distribution of total operating expenses by geographical area was as follows:

	Three Months Ended September 30,				Nine Months Ended September 30,
Operating expenses	2018		2017		2018		2017
Ireland	$	22,444	$	7,010	$	45,219	$	16,684
U.S.		2,796	$	1,445		8,027		3,726
Total	$	25,240	$	8,455	$	53,246	$	20,410

Schedule of Distribution of Long-Lived Assets by Geographical Area

The distribution of long-lived assets by geographical area was as follows:

Long lived assets	September 30, 2018		December 31, 2017
Ireland	$	3,712	$	2,341
U.S.		246		243
Total	$	3,958	$	2,584

Quarterly report pursuant to Section 13 or 15(d)

Summary of Significant Accounting Policies (Tables)