Quarterly report pursuant to Section 13 or 15(d)

Commitment and Contingencies - Additional Information (Details)

Commitment and Contingencies - Additional Information (Details)	1 Months Ended
	Sep. 30, 2018 USD ($) Milestone	Jun. 30, 2018 USD ($)	Mar. 31, 2018 USD ($)	Apr. 30, 2017 USD ($)	Dec. 31, 2016 USD ($)	Dec. 31, 2018 USD ($)	Dec. 31, 2017 USD ($)	Jun. 30, 2016 USD ($)	Nov. 18, 2015 USD ($)
Other Commitments [Line Items]
Purchase obligation	$ 1,742,000						$ 599,000	$ 2,903,000
Pfizer License Agreement
Other Commitments [Line Items]
Milestone payments	$ 7,500,000
Number of clinical milestone payments \| Milestone	2
Pfizer License Agreement \| Scenario Forcast
Other Commitments [Line Items]
Accrued milestone liability						$ 7,500,000
Pfizer License Agreement \| Minimum
Other Commitments [Line Items]
Potential future regulatory milestone and sales milestone payments upon achievement of net sales									$ 250,000,000
Pfizer License Agreement \| Maximum
Other Commitments [Line Items]
Potential future regulatory milestone and sales milestone payments upon achievement of net sales									$ 1,000,000,000
Supplemental Agreement
Other Commitments [Line Items]
Purchase obligation		$ 2,380,000
Commercial Unit Lease Agreement \| Dublin
Other Commitments [Line Items]
Operating lease agreement, term of contract		20 years
Operating lease agreement, break option term of contract		10 years
Operating lease agreement, commencement period		2018-06
Annual lease payments		$ 319,000
Operating lease agreement, rental review		5 years
Security deposit		$ 813,000
Office Space Lease Agreement \| Dublin
Other Commitments [Line Items]
Operating lease agreement, term of contract					10 years
Annual lease payments					$ 335,000
Operating lease agreement, renewal term					5 years
Operating lease agreement, commencement date					Dec. 01, 2016
Operating lease agreement, expiration date					Dec. 01, 2026
Operating lease agreement, review period					2022-12
Office Space Lease Agreement \| Dublin \| Other Assets
Other Commitments [Line Items]
Security deposit					$ 335,000
Office Space Lease Agreement \| Chicago
Other Commitments [Line Items]
Operating lease agreement, term of contract			5 years
Operating lease agreement, commencement period			2018-06
Annual lease payments			$ 258,000
Security deposit			$ 120,000
Operating lease agreement, renewal term			5 years
Office Space Lease Agreement \| Connecticut
Other Commitments [Line Items]
Operating lease agreement, term of contract				5 years
Operating lease agreement, commencement period				2017-07
Annual lease payments				$ 131,000
Operating lease agreement, renewal term				3 years
Office Space Lease Agreement \| Connecticut \| Other Assets
Other Commitments [Line Items]
Security deposit				$ 17,000