Quarterly report pursuant to Section 13 or 15(d)

Summary of Significant Accounting Policies (Tables)

Summary of Significant Accounting Policies (Tables)

6 Months Ended

Jun. 30, 2019

Schedule of Potentially Dilutive Securities Excluded from Computation of Diluted Weighted-Average Shares Outstanding

The following potentially dilutive securities have been excluded from the computation of diluted weighted-average shares outstanding as they would be anti-dilutive:

	Six Months Ended
	June 30, 2019		June 30, 2018
Options to purchase ordinary shares		1,158,079		696,112
Unvested restricted ordinary shares		34,162		143,076
Unvested restricted share units		31,367		36,924
Unvested performance restricted share units		50,000		—
Warrants		19,890		19,890
Total		1,293,498		896,002

Schedule of Distribution of Total Operating Expenses by Geographical Area

The distribution of total operating expenses by geographical area was as follows:

	Three Months Ended June 30,				Six Months Ended June 30,
Operating expenses	2019		2018		2019		2018
Ireland	$	24,261	$	12,811	$	41,697	$	22,775
U.S.		3,117		2,800		6,184		5,230
Total	$	27,378	$	15,611	$	47,881	$	28,005

Schedule of Distribution of Long-Lived Assets by Geographical Area

The distribution of long-lived assets by geographical area was as follows:

Long lived assets	June 30, 2019		December 31, 2018
Ireland	$	9,809	$	4,565
U.S.		2,200		245
Total	$	12,009	$	4,810