Quarterly report pursuant to Section 13 or 15(d)

Summary of Significant Accounting Policies (Tables)

Summary of Significant Accounting Policies (Tables)

3 Months Ended

Mar. 31, 2019

Schedule of Potentially Dilutive Securities Excluded from Computation of Diluted Weighted-Average Shares Outstanding

The following potentially dilutive securities have been excluded from the computation of diluted weighted-average shares outstanding as they would be anti-dilutive:

	Three Months Ended
	March 31, 2019		March 31, 2018
Options to purchase ordinary shares		1,091,238		248,128
Preferred shares convertible into ordinary shares		—		7,396,313
Unvested restricted ordinary shares		60,250		163,523
Unvested restricted share units		36,924		—
Unvested performance restricted share units		50,000		—
Warrants		19,890		—
Total		1,258,302		7,807,964

Schedule of Distribution of Total Operating Expenses by Geographical Area

The distribution of total operating expenses by geographical area was as follows:

	Three Months Ended
Operating expenses	March 31, 2019		March 31, 2018
Ireland	$	17,436	$	9,964
U.S.		3,067	$	2,430
Total	$	20,503	$	12,394

Schedule of Distribution of Long-Lived Assets by Geographical Area

The distribution of long-lived assets by geographical area was as follows:

Long lived assets	March 31, 2019		December 31, 2018
Ireland	$	9,970	$	4,565
U.S.		2,256		245
Total	$	12,226	$	4,810