Quarterly report pursuant to Section 13 or 15(d)

Summary of Significant Accounting Policies (Tables)

Summary of Significant Accounting Policies (Tables)

9 Months Ended

Sep. 30, 2020

Schedule of Potentially Dilutive Securities Excluded from Computation of Diluted Weighted-Average Shares Outstanding

For the periods presented, the following ordinary shares underlying the options, unvested restricted ordinary shares, unvested restricted share units, unvested performance restricted share units and the warrants have been excluded from the calculation because they would be anti-dilutive.

	Nine Months Ended
	September 30, 2020		September 30, 2019
Options to purchase ordinary shares		1,147,490		1,150,439
Unvested restricted ordinary shares		—		8,542
Unvested restricted share units		—		31,367
Unvested performance restricted share units		1,042,000		50,000
Warrants		3,636,229		19,890
Total		5,825,719		1,260,238

Schedule of Distribution of Total Operating Expenses by Geographical Area

The distribution of total operating expenses by geographical area was as follows:

	Three Months Ended September 30,				Nine Months Ended September 30,
Operating expenses	2020		2019		2020		2019
Ireland	$	4,859	$	28,309	$	19,931	$	70,006
U.S.		1,476		2,690		7,551		8,874
Total	$	6,335	$	30,999	$	27,482	$	78,880

Schedule of Distribution of Long-Lived Assets by Geographical Area

The distribution of long-lived assets by geographical area was as follows:

Long-lived assets	September 30, 2020		December 31, 2019
Ireland	$	11,041	$	10,936
U.S.		3,104		3,037
Total	$	14,145	$	13,973