Quarterly report [Sections 13 or 15(d)]

Debt - Additional Information (Details)

v3.25.2
Debt - Additional Information (Details)
3 Months Ended 6 Months Ended 48 Months Ended
May 13, 2025
Jan. 31, 2025
USD ($)
Oct. 28, 2024
Sep. 08, 2020
USD ($)
Debtinstrument
Jan. 21, 2020
USD ($)
Debtinstrument
Nov. 18, 2015
USD ($)
Jun. 30, 2025
USD ($)
Jun. 30, 2024
USD ($)
Jun. 30, 2025
USD ($)
Jun. 30, 2024
USD ($)
Jan. 31, 2025
USD ($)
shares
Apr. 28, 2025
$ / shares
Apr. 27, 2018
USD ($)
$ / shares
shares
Debt Instrument [Line Items]                          
Warrants to purchase preferred shares, exercise price | $ / shares                       $ 0.01  
Accretion of debt discounts and deferred financing costs                 $ 194,000 $ 1,138,000      
Aggregate principal amount of exchangeable notes                     $ 40,691,000    
Accrued and unpaid interest                     $ 3,071,000    
Issuance of ordinary shares on conversion of exchangeable notes (in shares) | shares                     3,760,155    
Aggregate principal amount                     $ 40,691,000    
Pfizer License Agreement                          
Debt Instrument [Line Items]                          
Regulatory milestone payments upon approval of product           $ 20,000,000              
Regulatory and sales milestone deferred payment annual rate           8.00%              
Regulatory and sales milestone deferred payment period     2 years                    
A&R Note and Letter Agreement | Maximum                          
Debt Instrument [Line Items]                          
Regulatory and sales milestone deferred payment annual rate 10.00%                        
A&R Note and Letter Agreement | Minimum                          
Debt Instrument [Line Items]                          
Regulatory and sales milestone deferred payment annual rate 8.00%                        
Debt modification percent 10.00%                        
Exchangeable Notes                          
Debt Instrument [Line Items]                          
Aggregate principal amount of exchangeable notes   $ 11,117,000                 40,691,000    
Accrued and unpaid interest                     3,071,000    
Aggregate principal amount   11,117,000                 40,691,000    
Accrued interest   $ 3,628,000                 3,628,000    
Exchangeable Notes | Private Placement                          
Debt Instrument [Line Items]                          
Aggregate principal amount of exchangeable notes                     40,691,000    
Aggregate principal amount                     $ 40,691,000    
Promissory Note                          
Debt Instrument [Line Items]                          
Interest expense             $ 449,000   $ 853,000        
Loan and Security Agreement | Silicon Valley Bank (SVB)                          
Debt Instrument [Line Items]                          
Loan and security agreement entered date                 Apr. 27, 2018        
Funded amount under agreement                         $ 15,000,000
Maximum amount available under agreement                         $ 30,000,000
Silicon Valley Bank and Life Sciences Fund II LLC | Ordinary Shares                          
Debt Instrument [Line Items]                          
Number of warrants to purchase ordinary shares | shares                         1,326
Silicon Valley Bank and Life Sciences Fund II LLC | Series B Convertible Preferred Shares                          
Debt Instrument [Line Items]                          
Number of warrants to purchase ordinary shares | shares                         19,890
Warrants to purchase preferred shares, exercise price | $ / shares                         $ 282.75
2025 Exchangeable Notes                          
Debt Instrument [Line Items]                          
Interest expense             0 $ 180,000 $ 88,000 361,000      
Accretion of debt discounts and deferred financing costs             $ 0 $ 569,000 $ 194,000 $ 1,138,000      
2025 Exchangeable Notes | Private Placement                          
Debt Instrument [Line Items]                          
Aggregate principal amount         $ 51,588,000                
Debt instrument price per unit         $ 1,000                
2025 Exchangeable Notes | Private Placement and Rights Offering                          
Debt Instrument [Line Items]                          
Aggregate principal amount       $ 51,808,000                  
Debt instrument interest rate         6.50%                
2025 Exchangeable Notes | Rights Offering                          
Debt Instrument [Line Items]                          
Aggregate principal amount       220,000                  
2020 Rights Offering | Private Placement                          
Debt Instrument [Line Items]                          
Debt instrument price per unit       1,000                  
2020 Rights Offering | Rights Offering                          
Debt Instrument [Line Items]                          
Aggregate principal amount       $ 220,000                  
RLNs | Private Placement                          
Debt Instrument [Line Items]                          
Aggregate principal amount         $ 103,000                
Number of debt instruments within each notes | Debtinstrument       50 50                
RLNs | Private Placement and Rights Offering                          
Debt Instrument [Line Items]                          
Aggregate principal amount       $ 500 $ 104,000                
RLNs | Rights Offering                          
Debt Instrument [Line Items]                          
Aggregate principal amount       440                  
Securities | Private Placement                          
Debt Instrument [Line Items]                          
Debt instrument price per unit       $ 1,000 $ 1,000