Quarterly report [Sections 13 or 15(d)]

Basis of Presentation - Additional Information (Details)

Basis of Presentation - Additional Information (Details)								3 Months Ended		12 Months Ended	48 Months Ended
	Feb. 19, 2025 USD ($)	Jan. 31, 2025 USD ($) shares	Dec. 10, 2024 USD ($)	Aug. 09, 2024 USD ($) $ / shares shares	Oct. 07, 2022 USD ($) $ / shares	Sep. 08, 2020 USD ($) Debtinstrument	Jan. 21, 2020 USD ($) Debtinstrument	Mar. 31, 2025 USD ($) $ / shares shares	Mar. 31, 2024 USD ($)	Dec. 31, 2024 USD ($) $ / shares shares	Jan. 31, 2025 USD ($) shares	Apr. 28, 2025 $ / shares shares	May 03, 2023 $ / shares	Oct. 17, 2022 USD ($)	Feb. 10, 2021 $ / shares	Feb. 08, 2021 $ / shares	Oct. 31, 2020 $ / shares	Oct. 27, 2020 $ / shares
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Net losses								$ 4,891,000	$ 7,101,000	$ 24,774,000
Accumulated deficit								$ 490,963,000		$ 486,072,000
Aggregate principal amount of exchangeable notes											$ 40,691,000
Ordinary shares, shares issued \| shares								35,686,616		31,534,233
Accrued and unpaid interest											3,071,000
Cash and cash equivalents								$ 12,652,000		$ 24,125,000
Ordinary shares, par value \| $ / shares								$ 0.01		$ 0.01			$ 0.01
Authorized amount for sale of stock	$ 150,000,000
Maximum
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Value of shares and securities may offer and sell														$ 100,000,000
Subsequent Events
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Ordinary shares, shares issued \| shares												3,040,000
Warrants to purchase ordinary shares, exercise price \| $ / shares												$ 0.01
Sales Agreement With H.C. Wainwright
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Ordinary shares, par value \| $ / shares					$ 0.01
Sales Agreement With H.C. Wainwright \| Maximum
Organization Consolidation And Presentation Of Financial Statements [Line Items]
May offer and sell ordinary shares for additional aggregate offering price			$ 25,000,000
May offer and sell ordinary shares for aggregate gross sales proceeds					$ 16,000,000
2024 Rights Offering
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Number of units sold \| shares				6,121,965
Subscription price per whole unit \| $ / shares				$ 1.21
Warrants to purchase ordinary shares, exercise price \| $ / shares				$ 1.21
Aggregate net proceeds from rights offering				$ 5,400,000
2024 Rights Offering \| 1-Year Warrant
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Number of shares that can be purchased with each warrant \| shares				0.5
Warrants to purchase ordinary shares, exercise price \| $ / shares								1.21
2024 Rights Offering \| 5-Year Warrants
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Warrants to purchase ordinary shares, exercise price \| $ / shares				$ 1.21				$ 1.21
October Offering
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Warrants to purchase ordinary shares, exercise price \| $ / shares																	$ 12.1875	$ 9.75
February Underwritten Offering
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Warrants to purchase ordinary shares, exercise price \| $ / shares															$ 21.5625	$ 21.5625
2025 Exchangeable Notes \| Private Placement and Rights Offering
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Aggregate principal amount						$ 51,800,000
Debt instrument interest rate							6.50%
2025 Exchangeable Notes \| Private Placement
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Aggregate principal amount							$ 51,588,000
Debt instrument price per unit							1,000
RLNs \| Private Placement and Rights Offering
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Aggregate principal amount						$ 500	100,000
RLNs \| Private Placement
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Aggregate principal amount							$ 103,000
Number of debt instruments within each notes \| Debtinstrument						50	50
Exchangeable Notes
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Aggregate principal amount of exchangeable notes		$ 11,117,000									$ 40,691,000
Ordinary shares, shares issued \| shares		3,760,155						3,760,155			3,760,155
Accrued and unpaid interest											$ 3,071,000
Accrued interest balance amount		$ 3,628,000
Repayment of aggregate principal amount		$ 11,117,000
Exchangeable Notes \| Private Placement
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Aggregate principal amount of exchangeable notes											$ 40,691,000