Quarterly report pursuant to Section 13 or 15(d)

Shareholders' Equity - Additional Information (Details)

Shareholders' Equity - Additional Information (Details) $ / shares in Units, $ in Thousands										1 Months Ended	3 Months Ended	14 Months Ended
	Feb. 12, 2021 $ / shares shares	Feb. 10, 2021 USD ($) $ / shares shares	Feb. 09, 2021 USD ($) $ / shares shares	Feb. 08, 2021 $ / shares shares	Feb. 03, 2021 $ / shares shares	Oct. 31, 2020 $ / shares shares	Oct. 27, 2020 $ / shares shares	Jul. 02, 2020 $ / shares shares	Jun. 03, 2020 $ / shares shares	Jun. 30, 2020 $ / shares shares	Mar. 31, 2022 USD ($) Vote $ / shares shares	Mar. 31, 2022 USD ($) $ / shares shares	Dec. 31, 2021 $ / shares shares	Mar. 31, 2021 shares	Jan. 28, 2021 $ / shares shares	Jun. 05, 2020 $ / shares shares	Apr. 27, 2018 $ / shares shares
Class Of Stock [Line Items]
Ordinary shares, shares issued											183,353,418	183,353,418	182,775,282
Ordinary shares, par value \| $ / shares											$ 0.01	$ 0.01	$ 0.01		$ 0.01
Proceeds from registered direct offerings, net of transaction costs \| $											$ 546
Number of warrants to purchase preferred shares											380,000	380,000
Ordinary shares, shares authorized											300,000,000	300,000,000	300,000,000		150,000,000
Number of vote per common share \| Vote											1
Common stock rights and preferences											The holders of ordinary shares currently have no preemptive or other subscription rights, and there are no redemption or sinking fund provisions with respect to such shares
Undesignated preferred shares, par value \| $ / shares											$ 0.01	$ 0.01	$ 0.01
Undesignated preferred shares, authorized											100,000,000	100,000,000	100,000,000
Undesignated preferred shares issued											0	0	0
Undesignated Preferred Shares
Class Of Stock [Line Items]
Undesignated preferred shares, par value \| $ / shares											$ 0.01	$ 0.01
Undesignated preferred shares, authorized											100,000,000	100,000,000
Designated Preferred Shares
Class Of Stock [Line Items]
Undesignated preferred shares issued											0	0		0
Silicon Valley Bank and Life Sciences Fund II LLC \| Series B Convertible Preferred Shares
Class Of Stock [Line Items]
Number of warrants to purchase preferred shares											19,890	19,890					19,890
Warrants to purchase preferred shares, exercise price \| $ / shares											$ 18.85	$ 18.85					$ 18.85
Exchangeable Notes
Class Of Stock [Line Items]
Ordinary shares, shares issued											53,888,331	53,888,331
Aggregate principal amount of exchangeable notes \| $												$ 39,201
Aggregate principal amount \| $											$ 12,607	$ 12,607
Ordinary Shares
Class Of Stock [Line Items]
Number of warrants to purchase preferred shares											19,890	19,890					19,890
October Offering
Class Of Stock [Line Items]
Ordinary shares, par value \| $ / shares											$ 0.01	$ 0.01
Proceeds from registered direct offerings, net of transaction costs \| $											$ 13,885
Number of warrants to purchase preferred shares						1,884,615					20,890,516	20,890,516
Warrants to purchase preferred shares, exercise price \| $ / shares						$ 0.8125	$ 0.65
Warrants expiry date						Oct. 22, 2025	Oct. 27, 2025
Percentage of ordinary shares issued to purchase warrants						7.00%
October Offering \| Maximum
Class Of Stock [Line Items]
Number of warrants to purchase preferred shares							20,192,307
February Underwritten Offering
Class Of Stock [Line Items]
Warrants to purchase preferred shares, exercise price \| $ / shares		$ 1.4375		$ 1.4375
Offering closing date		Feb. 10, 2021		Feb. 08, 2021
Additional ordinary shares that can be purchased by underwriter		5,217,391
Warrants expiry date		Feb. 03, 2026		Feb. 03, 2026
Percentage of ordinary shares issued to purchase warrants		7.00%		7.00%
February Underwritten Offering \| Maximum
Class Of Stock [Line Items]
Number of warrants to purchase preferred shares		365,217		2,434,783
February Underwritten Offering \| Underwriting Agreement
Class Of Stock [Line Items]
Ordinary shares, shares issued					34,782,609
Ordinary shares, par value \| $ / shares					$ 0.01
Offering closing date					Feb. 08, 2021
February Underwritten Offering \| Pursuant to the Underwriting Agreement
Class Of Stock [Line Items]
Ordinary shares, shares issued		40,000,000
Aggregate gross proceeds from ordinary shares \| $		$ 46,000
Proceeds from registered direct offerings, net of transaction costs \| $		$ 42,119
Additional ordinary shares that can be purchased by underwriter		5,217,391
February 2021 Underwritten Offering \| Underwriting Agreement
Class Of Stock [Line Items]
Offering price per share \| $ / shares					$ 1.15
Private Placement \| Securities Purchase Agreement
Class Of Stock [Line Items]
Number of warrants to purchase preferred shares																208,023
Warrants to purchase preferred shares, exercise price \| $ / shares									$ 1.62							$ 2.1031
Warrants expiry date									Dec. 05, 2025		Apr. 27, 2028
Private Placement \| Securities Purchase Agreement \| Maximum
Class Of Stock [Line Items]
Number of warrants to purchase preferred shares									1,485,885
Private Placement \| June 30 SPA
Class Of Stock [Line Items]
Proceeds from registered direct offerings, net of transaction costs \| $											$ 1,796
Number of warrants to purchase preferred shares								236,088			1,264,757	1,264,757
Warrants to purchase preferred shares, exercise price \| $ / shares								$ 1.8531		$ 1.42
Warrants expiry date								Jun. 30, 2025		Jan. 02, 2026
Percentage of ordinary shares issued to purchase warrants								7.00%
Private Placement \| June 30 SPA \| Maximum
Class Of Stock [Line Items]
Number of warrants to purchase preferred shares										1,686,343
Private Placement \| Exchangeable Notes
Class Of Stock [Line Items]
Aggregate principal amount of exchangeable notes \| $												$ 39,201
February Registered Direct Offering
Class Of Stock [Line Items]
Ordinary shares, shares issued			17,500,000
Ordinary shares, par value \| $ / shares			$ 0.01
Offering price per share \| $ / shares			$ 2.00
Aggregate gross proceeds from ordinary shares \| $			$ 35,000
Proceeds from registered direct offerings, net of transaction costs \| $			$ 32,235
Warrants to purchase preferred shares, exercise price \| $ / shares	$ 2.50
Offering closing date	Feb. 12, 2021		Feb. 12, 2021
Warrants expiry date	Feb. 09, 2026
Percentage of ordinary shares issued to purchase warrants	7.00%
February Registered Direct Offering \| Maximum
Class Of Stock [Line Items]
Number of warrants to purchase preferred shares	1,225,000