Quarterly report pursuant to Section 13 or 15(d)

Summary of Significant Accounting Policies (Tables)

Summary of Significant Accounting Policies (Tables)

3 Months Ended

Mar. 31, 2022

Schedule of Potentially Dilutive Securities Excluded from Computation of Diluted Weighted-Average Shares Outstanding

For the periods presented, the following ordinary shares underlying the options, unvested restricted share units, unvested performance restricted share units, warrants and the Exchangeable Notes have been excluded from the calculation because they would be anti-dilutive.


	Three months ended
	March 31, 2022		March 31, 2021
Options to purchase ordinary shares		16,227,246		690,733
Unvested restricted share units		1,236,573		1,198,136
Unvested performance restricted share units		—		407,000
Warrants		7,202,878		8,240,955
Exchangeable Notes		18,524,277		19,828,296
Total		43,190,974		30,365,120

Schedule of Distribution of Total Operating Expenses by Geographical Area

The distribution of total operating expenses by geographical area was as follows:


	Three Months Ended March 31,
Operating expenses	2022		2021
Ireland	$	4,549	$	3,918
U.S.		2,811		1,884
Bermuda		13		45
Total	$	7,373	$	5,847

Schedule of Distribution of Long-Lived Assets by Geographical Area

The distribution of long-lived assets by geographical area was as follows:


Long-lived assets	March 31, 2022		December 31, 2021
Ireland	$	7,105	$	7,601
U.S.		513		578
Total	$	7,618	$	8,179