Exhibit 22.1

Subsidiary Issuers and Subsidiary Guarantors of Guaranteed Securities

 

Guaranteed Security

Subsidiary Issuer

Co-Guarantors

6.500% Exchangeable Senior Subordinated Notes due 2025

Iterum Therapeutics Bermuda Limited

Iterum Therapeutics International Limited (subsidiary guarantor)

Iterum Therapeutics US Limited (subsidiary guarantor)

Iterum Therapeutics US Holding Limited (subsidiary guarantor)

Iterum Therapeutics plc (parent guarantor)

Limited Recourse Royalty-Linked Subordinated Notes

Iterum Therapeutics Bermuda Limited

Iterum Therapeutics International Limited (subsidiary guarantor)

Iterum Therapeutics US Limited (subsidiary guarantor)

Iterum Therapeutics US Holding Limited (subsidiary guarantor)

Iterum Therapeutics plc (parent guarantor)