Exhibit 22.1
Subsidiary Issuers and Subsidiary Guarantors of Guaranteed Securities
| Guaranteed Security | Subsidiary Issuer | Co-Guarantors | 
| 6.500% Exchangeable Senior Subordinated Notes due 2025 | Iterum Therapeutics Bermuda Limited | •Iterum Therapeutics International Limited (subsidiary guarantor) •Iterum Therapeutics US Limited (subsidiary guarantor) •Iterum Therapeutics US Holding Limited (subsidiary guarantor) •Iterum Therapeutics plc (parent guarantor) | 
| Limited Recourse Royalty-Linked Subordinated Notes | Iterum Therapeutics Bermuda Limited | •Iterum Therapeutics International Limited (subsidiary guarantor) •Iterum Therapeutics US Limited (subsidiary guarantor) •Iterum Therapeutics US Holding Limited (subsidiary guarantor) •Iterum Therapeutics plc (parent guarantor) |