UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, DC 20549
FORM 10-Q
(Mark One)
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QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 |
For the quarterly period ended March 31, 2019
OR
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TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 |
For the transition period from to
Commission File Number: 001-38503
Iterum Therapeutics plc
(Exact Name of Registrant as Specified in its Charter)
Ireland |
98-1283148 |
(State or other jurisdiction of incorporation or organization) |
(I.R.S. Employer Identification No.) |
Block 2 Floor 3, Harcourt Centre,
Harcourt Street,
Dublin 2, Ireland
(Address of principal executive offices)
Not applicable
(Zip Code)
(+353) 1 903-8920
(Registrant’s telephone number, including area code)
Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes ☒ No ☐
Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§ 232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files). Yes ☒ No ☐
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.
Large accelerated filer |
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Accelerated filer |
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Non-accelerated filer |
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Smaller reporting company |
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Emerging growth company |
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If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☒
Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes ☐ No ☒
Securities registered pursuant to Section 12(b) of the Act:
Title of each class |
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Trading Symbol(s) |
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Name of each exchange on which registered |
Ordinary Shares, $0.01 par value per share |
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ITRM |
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The Nasdaq Stock Market LLC |
As of April 30, 2019, the registrant had 14,369,218 ordinary shares, $0.01 par value per share, outstanding.
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Page |
PART I. |
1 |
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Item 1. |
1 |
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1 |
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Condensed Consolidated Statements of Operations and Comprehensive Loss |
2 |
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3 |
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Notes to Unaudited Condensed Consolidated Financial Statements |
4 |
Item 2. |
Management’s Discussion and Analysis of Financial Condition and Results of Operations |
17 |
Item 3. |
26 |
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Item 4. |
26 |
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PART II. |
27 |
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Item 1. |
27 |
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Item 1A. |
27 |
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Item 2. |
72 |
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Item 6. |
73 |
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74 |
ii
SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS
This Quarterly Report on Form 10-Q contains forward-looking statements that involve risks and uncertainties. All statements other than statements of historical facts contained in this Quarterly Report are forward-looking statements. In some cases, you can identify forward-looking statements by words such as “anticipate,” “believe,” “contemplate,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “plan,” “potential,” “predict,” “project,” “seek,” “should,” “target,” “will,” “would,” or the negative of these words or other comparable terminology. These forward-looking statements include, but are not limited to, statements about:
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our use of cash reserves; |
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the initiation, timing, progress and results of our preclinical studies and clinical trials, and our research and development programs; |
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our ability to retain the continued service of our key professionals and to identify, hire and retain additional qualified professionals; |
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our ability to advance product candidates into, and successfully complete, clinical trials; |
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the potential advantages of our product candidates; |
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the timing or likelihood of regulatory filings and approvals; |
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the commercialization of our product candidates, if approved; |
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our ability to draw down our second term loan with Silicon Valley Bank; |
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our manufacturing plans; |
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our sales, marketing and distribution capabilities and strategy; |
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market acceptance of any product we successfully commercialize; |
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the pricing, coverage and reimbursement of our product candidates, if approved; |
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the implementation of our business model, strategic plans for our business and product candidates; |
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the scope of protection we are able to establish and maintain for intellectual property rights covering our product candidates; |
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our ability to enter into strategic arrangements, collaborations and/or commercial partnerships in the United States and other territories and the potential benefits of such arrangements; |
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our estimates regarding expenses, capital requirements and needs for additional financing; |
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our expectations regarding how far into the future our cash on hand will fund our ongoing operations; |
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our financial performance; and |
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developments relating to our competitors and our industry. |
These forward-looking statements are subject to a number of risks, uncertainties and assumptions, including those described in “Risk Factors” and elsewhere in this Quarterly Report. Moreover, we operate in a very competitive and rapidly changing environment, and new risks emerge from time to time. It is not possible for our management to predict all risks, nor can we assess the impact of all factors on our business or the extent to which any factor, or combination of factors, may cause actual results to differ materially from those contained in any forward-looking statements we may make. In light of these risks, uncertainties and assumptions, the forward-looking events and circumstances discussed in this Quarterly Report may not occur and actual results could differ materially and adversely from those anticipated or implied in the forward-looking statements.
You should not rely upon forward-looking statements as predictions of future events. Although we believe that the expectations reflected in the forward-looking statements are reasonable, we cannot guarantee that the future results, levels of activity, performance or events and circumstances reflected in the forward-looking statements will be achieved or occur. We undertake no obligation to update publicly any forward-looking statements for any reason after the date of this Quarterly Report to conform these statements to new information, actual results or to changes in our expectations, except as required by law.
You should read this Quarterly Report and the documents that we have filed with the Securities and Exchange Commission (SEC), as exhibits to this Quarterly Report with the understanding that our actual future results, levels of activity, performance, and events and circumstances may be materially different from what we expect.
iii
In addition, statements that “we believe” and similar statements reflect our beliefs and opinions on the relevant subject. These statements are based upon information available to us as of the date of this Quarterly Report, and while we believe such information forms a reasonable basis for such statements, such information may be limited or incomplete, and our statements should not be read to indicate that we have conducted an exhaustive inquiry into, or review of, all potentially available relevant information. These statements are inherently uncertain and investors are cautioned not to unduly rely upon these statements.
iv
ITERUM THERAPEUTICS PLC
Condensed Consolidated Balance Sheets
(In thousands except share and per share data)
(Unaudited)
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March 31, |
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December 31, |
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2019 |
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2018 |
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Assets |
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Current assets: |
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Cash and cash equivalents |
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$ |
64,603 |
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$ |
44,551 |
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Short-term investments |
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4,997 |
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40,000 |
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Prepaid expenses and other current assets |
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7,188 |
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8,390 |
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Current portion of restricted cash |
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30 |
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30 |
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Total current assets |
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76,818 |
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92,971 |
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Property and equipment, net |
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675 |
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700 |
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Restricted cash, less current portion |
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90 |
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90 |
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Other assets |
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11,551 |
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4,110 |
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Total assets |
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$ |
89,134 |
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$ |
97,871 |
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Liabilities and Shareholders’ Equity |
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Current liabilities: |
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Accounts payable |
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$ |
6,176 |
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$ |
4,041 |
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Accrued expenses |
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8,696 |
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7,046 |
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Current portion of long-term debt |
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2,056 |
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1,019 |
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Income taxes payable |
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248 |
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113 |
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Other current liabilities |
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442 |
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— |
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Total current liabilities |
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17,618 |
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12,219 |
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Long-term debt, less current portion |
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12,139 |
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13,079 |
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Other liabilities |
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7,747 |
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951 |
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Total liabilities |
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$ |
37,504 |
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$ |
26,249 |
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Commitments and contingencies (Note 12) |
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Shareholders’ equity: |
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Ordinary shares, $0.01 par value per share: 50,000,000 shares authorized at March 31, 2019 and December 31, 2018; 14,367,441 shares issued at March 31, 2019; 14,352,046 shares issued at December 31, 2018 |
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144 |
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144 |
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Additional paid-in capital |
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203,859 |
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203,271 |
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Accumulated deficit |
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(152,373 |
) |
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(131,793 |
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Total shareholders' equity |
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51,630 |
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71,622 |
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Total liabilities and shareholders’ equity |
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$ |
89,134 |
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$ |
97,871 |
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The accompanying notes are an integral part of these condensed consolidated financial statements
1
Condensed Consolidated Statements of Operations and Comprehensive Loss
(In thousands, except share and per share data)
(Unaudited)
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Three Months Ended |
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March 31, |
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2019 |
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2018 |
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Revenue |
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$ |
37 |
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$ |
191 |
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Operating expenses: |
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Research and development |
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$ |
(17,387 |
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$ |
(10,879 |
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General and administrative |
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(3,116 |
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(1,515 |
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Total operating expenses |
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(20,503 |
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(12,394 |
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Operating loss |
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(20,466 |
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(12,203 |
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Interest (expense) / income, net |
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(104 |
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85 |
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Other income, net |
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124 |
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61 |
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Total other income |
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20 |
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146 |
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Loss before income taxes |
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(20,446 |
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(12,057 |
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Income tax expense |
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(134 |
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(89 |
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Net loss and comprehensive loss |
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(20,580 |
) |
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(12,146 |
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Net loss attributable to ordinary shareholders |
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$ |
(20,580 |
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$ |
(12,146 |
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Net loss per share attributable to ordinary shareholders – basic and diluted |
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$ |
(1.44 |
) |
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$ |
(61.36 |
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Weighted average ordinary shares outstanding – basic and diluted |
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14,290,437 |
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197,949 |
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The accompanying notes are an integral part of these condensed consolidated financial statements
2
Condensed Consolidated Statements of Cash flows
(In thousands, except share and per share data)
(Unaudited)
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Three Months Ended March 31, |
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2019 |
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2018 |
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Cash flows from operating activities: |
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Net loss |
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$ |
(20,580 |
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$ |
(12,146 |
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Adjustments to reconcile net loss to cash used in operating activities: |
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Depreciation |
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35 |
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31 |
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Share-based compensation expense |
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540 |
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149 |
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Gain on short term investments |
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(88 |
) |
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— |
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Non-cash gain on short term investments |
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(9 |
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(23 |
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Interest on short-term investments |
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(11 |
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— |
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Amortization of SVB loan |
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98 |
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— |
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Other |
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29 |
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— |
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Changes in operating assets and liabilities: |
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Prepaid expenses and other current assets |
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1,193 |
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(793 |
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Other assets |
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(191 |
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(52 |
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Accounts payable |
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2,135 |
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422 |
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Accrued expenses |
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1,662 |
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692 |
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Income taxes |
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134 |
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82 |
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Other liabilities |
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— |
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(2 |
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Net cash used in operating activities |
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(15,053 |
) |
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(11,640 |
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Cash flows from investing activities: |
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Purchases of property and equipment |
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(10 |
) |
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(21 |
) |
Purchases of short-term investments |
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— |
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(6,372 |
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Proceeds from sale of short-term investments |
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35,100 |
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15,750 |
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Net cash generated by investing activities |
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35,090 |
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9,357 |
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Cash flows from financing activities: |
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Proceeds from issuance of Series B convertible preferred shares, net of issuance costs |
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— |
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32,176 |
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Proceeds from exercise of shares options |
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49 |
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— |
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Net cash provided by financing activities |
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49 |
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32,176 |
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Effect of exchange rates on cash and cash equivalents |
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(34 |
) |
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— |
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Net increase in cash, cash equivalents and restricted cash |
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20,052 |
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29,893 |
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Cash, cash equivalents and restricted cash, at beginning of period |
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44,671 |
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8,485 |
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Cash, cash equivalents and restricted cash, at end of period |
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$ |
64,723 |
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$ |
38,378 |
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Supplemental Disclosure of Cash Flow Information: |
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Income tax paid—U.S. |
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$ |
— |
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$ |
— |
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Interest paid |
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$ |
350 |
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$ |
— |
|
The accompanying notes are an integral part of these condensed consolidated financial statements
3
Notes to Condensed Consolidated Financial Statements
(In thousands, except share and per share data)
(Unaudited)
1. Basis of Presentation
Iterum Therapeutics plc (the “Company”) was incorporated under the laws of the state of Ireland in June 2015 as a limited company and re-registered as a public limited company on March 20, 2018. The Company maintains its registered office at Block 2 Floor 3, Harcourt Centre, Harcourt Street, Dublin 2, Ireland. The Company commenced operations in November 2015. The Company licensed global rights to its novel anti-infective compound, sulopenem, from Pfizer Inc. (Pfizer). The Company is a clinical-stage pharmaceutical company dedicated to developing and commercializing sulopenem to be potentially the first and only oral and intravenous (IV) branded penem available globally.
Since inception, the Company has devoted substantially all of its efforts to research and development, recruiting management and technical staff, and raising capital, and has financed its operations through the issuance of ordinary and convertible preferred shares, debt raised under a financing arrangement with Silicon Valley Bank (SVB) and a sub-award from the Trustees of Boston University under the Combating Antibiotic Resistant Bacteria Biopharmaceutical Accelerator (CARB-X) program. The Company has not generated any product revenue. The Company is subject to risks and uncertainties common to early-stage companies in the pharmaceutical industry, including, but not limited to, the ability to secure additional capital to fund operations, failure to successfully develop and commercialize its product candidates, development by competitors of new technological innovations, dependence on key personnel, protection of proprietary technology and compliance with government regulations. Product candidates currently under development will require significant additional research and development efforts, including preclinical and clinical testing and regulatory approval prior to commercialization.
Even if the Company’s product development efforts are successful, it is uncertain when, if ever, the Company will realize significant revenue from product sales.
The accompanying condensed consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States of America (GAAP) and include the accounts of the Company and its subsidiaries.
On May 15, 2018, the Company’s shareholders approved a consolidation of its ordinary shares and convertible preferred shares at a 1-for-15.71 ratio (the “Reverse Share Split”), effective on that date. Fractional entitlements to ordinary shares and convertible preferred shares arising as a result of the Reverse Share Split were rounded down to the nearest whole number for each holder of ordinary shares and convertible preferred shares. Those fractional entitlements were aggregated and surrendered to the Company for cancellation. Immediately following the Reverse Share Split, the Company redenominated its ordinary shares and convertible preferred shares from $0.01571 (the nominal value resulting from the Reverse Share Split) per share to $0.01 per share (the “Renominalisation”). All issued and outstanding ordinary shares, convertible preferred shares, options for ordinary shares, restricted share awards, warrants and per share amounts have been retroactively adjusted to reflect this Reverse Share Split and Renominalisation for all periods presented.
On May 30, 2018, the Company completed an initial public offering (IPO) of its ordinary shares, and issued and sold 6,150,000 ordinary shares at a public offering price of $13.00 per share, resulting in net proceeds of $71.8 million after deducting underwriting discounts and commissions and offering costs payable by the Company. On June 26, 2018, the Company issued and sold an additional 200,000 ordinary shares at the IPO price of $13.00 per share pursuant to the underwriters’ partial exercise of their option to purchase additional ordinary shares, resulting in additional net proceeds of $2.4 million after deducting underwriting discounts and commissions and offering costs payable by the Company. Aggregate net proceeds from the IPO totaled $74.2 million after deducting underwriting discounts and commissions and offering costs payable by the Company.
In accordance with Accounting Standards Update (ASU) 2014-15, Disclosure of Uncertainties about an Entity’s Ability to Continue as a Going Concern (Subtopic 205-40), the Company has evaluated whether there are conditions and events, considered in aggregate, that raise substantial doubt about the Company’s ability to continue as a going concern within one year of the date of issue of the quarterly condensed consolidated financial statements.
The Company has incurred operating losses since inception, including net losses of $20,580 and $12,146 for the three months ended March 31, 2019 and 2018, respectively, and a net loss of $77,056 for the year ended December 31, 2018. The Company had an accumulated deficit of $152,373 as of March 31, 2019. The Company expects to continue to incur net losses for the foreseeable future and is highly dependent on its ability to find additional sources of funding in the form of debt or equity financing to fund its operations. Management believe that its cash and cash equivalents balance of $64,603 and short-term investments balance of $4,997 at March 31, 2019, together with the $15.0 million potentially available under the secured credit facility with SVB, are sufficient to fund operations for at least one year from the date the condensed consolidated financial statements are issued. In making this assessment management have considered the Company’s available cash resources, future financing options available to the Company, the planned operations of the Company and the ability to adjust its plans if required. The $15.0 million under the secured credit facility with SVB
4
ITERUM THERAPEUTICS PLC
Notes to Condensed Consolidated Financial Statements
(In thousands, except share and per share data)
(Unaudited)
will be available to the Company through October 31, 2019, upon satisfaction of either (i) the achievement by the Company of both non-inferiority and superiority primary endpoints from its Phase 3 uncomplicated urinary tract infection (uUTI) trial, as well as reporting satisfactory safety data from the trial, or (ii) the achievement of non-inferiority primary endpoints from both its Phase 3 uUTI and complicated urinary tract infection (cUTI) trials, as well as reporting satisfactory safety data from the trials. The inability to obtain funding, as and when needed, would have a negative impact on the Company’s financial condition and ability to pursue its business strategies. If the Company is unable to obtain funding, the Company could be forced to delay, reduce or eliminate some or all of its research and development programs or commercialization efforts, which could adversely affect its business prospects.
The Company expects to seek additional funding in order to continue to fund its operations through public or private financing of debt or equity or collaboration agreements. Although management intends to pursue plans to obtain additional funding to finance its operations, there is no assurance that the Company will be successful in obtaining sufficient funding on terms acceptable to the Company to fund continuing operations, if at all.
The accompanying condensed consolidated financial statements do not include any adjustments that might result from the outcome of this uncertainty. Accordingly, the condensed consolidated financial statements have been prepared on a basis that assumes the Company will continue as a going concern and which contemplates the realization of assets and satisfaction of liabilities and commitments in the ordinary course of business.
Interim Financial Information
The condensed consolidated balance sheet at December 31, 2018 was derived from audited financial statements, but does not include all disclosures required by GAAP. The accompanying unaudited condensed consolidated financial statements as of March 31, 2019, have been prepared by the Company pursuant to the rules and regulations of the Securities and Exchange Commission (SEC) for interim financial statements. Certain information and footnote disclosures normally included in financial statements prepared in accordance with GAAP have been condensed or omitted pursuant to such rules and regulations. These condensed consolidated financial statements should be read in conjunction with the Company’s audited consolidated financial statements and the notes thereto for the year ended December 31, 2018, included in the Company’s Annual Report on Form 10-K filed with the SEC on March 25, 2019. In the opinion of management, all adjustments, consisting only of normal recurring adjustments necessary for a fair statement of the Company’s financial position as of March 31, 2019, and results of operations for the three months ended March 31, 2019 and 2018, and cash flows for the three months ended March 31, 2019 and 2018 have been made. The results of operations for the three months ended March 31, 2019 are not necessarily indicative of the results of operations that may be expected for the year ending December 31, 2019.
2. Summary of Significant Accounting Policies
There have been no material changes in the Company’s significant accounting policies, other than the adoption of accounting pronouncements below, as compared to the significant accounting policies described in the Company’s Annual Report on Form 10-K for the year ended December 31, 2018.
Use of Estimates
The preparation of financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of expenses during the reporting period. Significant estimates and assumptions reflected in these condensed consolidated financial statements include, but are not limited to, the accrual for research and development expenses, revenue from grant awards, the valuation of restricted ordinary shares and the valuation of share-based compensation awards. The Company bases its estimates on historical experience, known trends and other market-specific or other relevant factors that it believes to be reasonable under the circumstances. On an ongoing basis, management evaluates its estimates as there are changes in circumstances, facts and experience. Actual results could differ materially from those estimates.
5
ITERUM THERAPEUTICS PLC
Notes to Condensed Consolidated Financial Statements
(In thousands, except share and per share data)
(Unaudited)
Basic and diluted net loss per ordinary share is determined by dividing net loss attributable to ordinary shareholders by the weighted-average ordinary shares outstanding during the period in accordance with Accounting Standard Codification (ASC) 260, Earnings per Share. For the periods presented, the ordinary shares underlying the convertible preferred shares and options, the unvested restricted ordinary shares, restricted share units, performance restricted share units and the warrants have been excluded from the calculation because they would be anti-dilutive.
The following potentially dilutive securities have been excluded from the computation of diluted weighted-average shares outstanding as they would be anti-dilutive:
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Three Months Ended |
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March 31, 2019 |
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March 31, 2018 |
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Options to purchase ordinary shares |
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1,091,238 |
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248,128 |
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Preferred shares convertible into ordinary shares |
|
|
— |
|
|
|
7,396,313 |
|
Unvested restricted ordinary shares |
|
|
60,250 |
|
|
|
163,523 |
|
Unvested restricted share units |
|
|
36,924 |
|
|
|
— |
|
Unvested performance restricted share units |
|
|
50,000 |
|
|
|
— |
|
Warrants |
|
|
19,890 |
|
|
|
— |
|
Total |
|
|
1,258,302 |
|
|
|
7,807,964 |
|
Segment Information
The Company determines and presents operating segments based on the information that is internally provided to the Chief Executive Officer, Chief Scientific Officer and Chief Financial Officer, who together are considered the Company’s chief operating decision maker, in accordance with ASC 280, Segment Reporting. The Company has determined that it operates as a single business segment, which is the development and commercialization of innovative treatments for drug resistant bacterial infections.
The distribution of total operating expenses by geographical area was as follows:
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Three Months Ended |
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|||||
Operating expenses |
|
March 31, 2019 |
|
|
March 31, 2018 |
|
||
Ireland |
|
$ |
17,436 |
|
|
$ |
9,964 |
|
U.S. |
|
|
3,067 |
|
|
$ |
2,430 |
|
Total |
|
$ |
20,503 |
|
|
$ |
12,394 |
|
The distribution of long-lived assets by geographical area was as follows:
Long lived assets |
|
March 31, 2019 |
|
|
December 31, 2018 |
|
||
Ireland |
|
$ |
9,970 |
|
|
$ |
4,565 |
|
U.S. |
|
|
2,256 |
|
|
|
245 |
|
Total |
|
$ |
12,226 |
|
|
$ |
4,810 |
|
Recently Adopted Accounting Pronouncements
In February 2016, the Financial Accounting Standards Board (FASB) issued ASU 2016-02, Leases (Topic 842) in order to increase transparency and comparability among organizations by recognizing lease assets and lease liabilities on the balance sheet for those leases classified as operating leases under prior GAAP. In July 2018, the FASB issued ASU 2018-11 Leases (Topic 842): Targeted Improvements which provides the option to adopt the standard retrospectively for each prior period presented, as initially set out in ASU 2016-02, or as of the adoption date with a cumulative-effect adjustment to the opening balance of retained earnings. In March 2019, the FASB issued ASU 2019-03 Leases (Topic 842): Codification Improvements amending the transition disclosures for Topic 842, in that all companies are exempt from certain interim period transition disclosure requirements.
ASU 2016-02 requires a lessee to recognize a liability to make lease payments (the lease liability) and a right-of-use asset, representing its right to use the underlying asset for the lease term, on the balance sheet. The Company adopted ASU 2016-02 in the
6
ITERUM THERAPEUTICS PLC
Notes to Condensed Consolidated Financial Statements
(In thousands, except share and per share data)
(Unaudited)
first quarter of 2019 utilizing the modified retrospective transition method with an effective date as the date of initial application. Consequently, prior period balances and disclosures have not been restated. The adoption of ASU 2016-02 on January 1, 2019 resulted in the recognition of right-of-use assets of $7.6 million and operating lease liabilities of $7.8 million, however, the adoption of the standard did not have an impact on the Company’s beginning retained earnings, results from operations or cash flows. See Note 7 for further information regarding the impact of the adoption of ASU 2016-02 on the Company's financial statements.
In July 2017, the FASB issued ASU 2017-11, Earnings Per Share (Topic 260), Distinguishing Liabilities from Equity (Topic 480), Derivatives and Hedging (Topic 815), I. Accounting for Certain Financial Instruments with Down Round Features, II. Replacement of the Indefinite Deferral for Mandatorily Redeemable Financial Instruments of Certain Nonpublic Entities and Certain Mandatorily Redeemable Noncontrolling Interests with a Scope Exception.
Part I applies to entities that issue financial instruments such as warrants, convertible debt or convertible preferred shares that contain down-round features. Part II replaces the indefinite deferral for certain mandatorily redeemable noncontrolling interests and mandatorily redeemable financial instruments of nonpublic entities contained within ASC Topic 480 with a scope exception and does not impact the accounting for these mandatorily redeemable instruments. ASU 2017-11 is required to be adopted for annual periods beginning after December 15, 2018, including interim periods within those fiscal years. The adoption of ASU 2017-11 did not have an impact on the condensed consolidated financial statements.
3. Fair Value of Financial Assets and Liabilities
The following table presents information about the Company’s financial assets that were carried at fair value on a recurring basis on the condensed consolidated balance sheet as of March 31, 2019 and December 31, 2018 and indicates the fair value hierarchy of the valuation inputs utilized to determine such fair value.
March 31, 2019 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Assets |
|
Total |
|
|
Level 1 |
|
|
Level 2 |
|
|
Level 3 |
|
||||
Short-term investments |
|
$ |
4,997 |
|
|
$ |
4,997 |
|
|
|
— |
|
|
|
— |
|
Other asset – advance payment to supplier |
|
|
2,617 |
|
|
|
— |
|
|
|
— |
|
|
|
2,617 |
|
Total |
|
$ |
7,614 |
|
|
|
4,997 |
|
|
|
— |
|
|
|
2,617 |
|
December 31, 2018 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Assets |
|
Total |
|
|
Level 1 |
|
|
Level 2 |
|
|
Level 3 |
|
||||
Short-term investments |
|
$ |
40,000 |
|
|
|
40,000 |
|
|
|
— |
|
|
|
— |
|
Other asset – advance payment to supplier |
|
|
2,649 |
|
|
|
— |
|
|
|
— |
|
|
|
2,649 |
|
Total |
|
$ |
42,649 |
|
|
|
40,000 |
|
|
|
— |
|
|
|
2,649 |
|
See Note 4 for further details on the short-term investments held. The other asset above relates to advance payments made to a supplier that were recorded at fair value using the discounted cash flow model (DCF) as of March 31, 2019 and December 31, 2018. The fair value measurements of these advance payments were determined based on significant unobservable inputs, including a discount rate of 15% and the expected time to recovery of the payment. Changes to the inputs described above are not expected to have a material impact on the company’s financial position and results of operations in any given period. See Note 12—Payments to Supplier, for further details on these advance payments.
The following table presents information about the Company’s long-term debt which was carried at amortized cost on the condensed consolidated balance sheet as of March 31, 2019 and December 31, 2018 and indicates the fair value hierarchy of the valuation inputs utilized to determine the approximate fair value.
7
ITERUM THERAPEUTICS PLC
Notes to Condensed Consolidated Financial Statements
(In thousands, except share and per share data)
(Unaudited)
|
|
|
|
|
Approximate |
|
|
|
|
|
|
|
|
|
|
|
|
|
||
Liabilities |
|
Book Value |
|
|
Fair Value |
|
|
Level 1 |
|
|
Level 2 |
|
|
Level 3 |
|
|||||
Current portion of long-term debt |
|
$ |
2,056 |
|
|
$ |
2,056 |
|
|
|
— |
|
|
|
2,056 |
|
|
|
— |
|
Long-term debt, less current portion |
|
|
12,139 |
|
|
|
11,850 |
|
|
|
— |
|
|
|
11,850 |
|
|
|
— |
|
Total |
|
$ |
14,195 |
|
|
$ |
13,906 |
|
|
|
— |
|
|
|
13,906 |
|
|
|
— |
|
December 31, 2018 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Liabilities |
|
Book Value |
|
|
Approximate Fair Value |
|
|
Level 1 |
|
|
Level 2 |
|
|
Level 3 |
|
|||||
Current portion of long-term debt |
|
$ |
1,019 |
|
|
$ |
1,019 |
|
|
|
— |
|
|
|
1,019 |
|
|
|
— |
|
Long-term debt, less current portion |
|
|
13,079 |
|
|
|
13,035 |
|
|
|
— |
|
|
|
13,035 |
|
|
|
— |
|
Total |
|
$ |
14,098 |
|
|
$ |
14,054 |
|
|
|
— |
|
|
|
14,054 |
|
|
|
— |
|
The book value of the current portion of long-term debt approximates its fair value due to the short-term nature of the balance. The fair value of long-term debt, less current portion was determined based on a DCF analysis using quoted market interest rates, without consideration of transaction costs, which represents a Level 2 basis of fair value measurement. The counterparty to the long-term debt is a major international financial institution.
The carrying amounts reported in the condensed consolidated balance sheets for prepaid expenses and other current assets, accounts payable, accrued expenses and other current liabilities approximate their fair value based on the short-term maturity of these instruments.
There have been no transfers of assets or liabilities between the fair value measurement levels.
4. Short-term investments
The Company classifies its short-term investments as available for sale. Short-term investments comprise highly liquid investments with minimum “A-” rated securities and as at period-end consist of corporate entity commercial paper with maturities of more than three months but less than one year at the date of purchase. Short-term investments as of March 31, 2019 have an average maturity of 0.12 years. The investments are reported at fair value with unrealized gains or losses recorded in the condensed consolidated statements of operations and comprehensive loss. Any differences between the cost and fair value of investments are represented by unrealized gains or losses. The fair value of short-term investments are represented by Level 1 fair value measurements – quoted prices in active markets for identical assets.
The following table represents the Company’s available for sale short-term investments by major security type as of March 31, 2019 and December 31, 2018:
March 31, 2019 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Maturity by period |
|
|||||
|
|
|
|
|
|
Unrealized |
|
|
Unrealized |
|
|
Fair Value |
|
|
Less than 1 |
|
|
|
|
|
||||
Available for sale |
|
Cost Total |
|
|
gains |
|
|
(losses) |
|
|
Total |
|
|
year |
|
|
1 to 5 years |
|
||||||
Commercial paper |
|
$ |
4,986 |
|
|
|
11 |
|
|
|
— |
|
|
|
4,997 |
|
|
|
4,997 |
|
|
|
— |
|
December 31, 2018 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Maturity by period |
|
|||||
|
|
|
|
|
|
Unrealized |
|
|
Unrealized |
|
|
Fair Value |
|
|
Less than 1 |
|
|
|
|
|
||||
Available for sale |
|
Cost Total |
|
|
gains |
|
|
(losses) |
|
|
Total |
|
|
year |
|
|
1 to 5 years |
|
||||||
Commercial paper |
|
$ |
35,745 |
|
|
|
272 |
|
|
|
(9 |
) |
|
|
36,008 |
|
|
|
36,008 |
|
|
|
— |
|
U.S. Treasury and Agency Bonds |
|
|
3,977 |
|
|
|
15 |
|
|
|
— |
|
|
|
3,992 |
|
|
|
3,992 |
|
|
|
— |
|
Total |
|
$ |
39,722 |
|
|
|
287 |
|
|
|
(9 |
) |
|
|
40,000 |
|
|
|
40,000 |
|
|
|
— |
|
8
ITERUM THERAPEUTICS PLC
Notes to Condensed Consolidated Financial Statements
(In thousands, except share and per share data)
(Unaudited)
5. Prepaid Expenses and Other Current Assets
Prepaid expenses and other current assets consist of the following:
|
|
March 31, 2019 |
|
|
December 31, 2018 |
|
||
Prepaid research and development expenses |
|
$ |
5,315 |
|
|
$ |
5,351 |
|
Short-term deposits |
|
|
873 |
|
|
|
959 |
|
Research and development tax credit receivable |
|
|
395 |
|
|
|
404 |
|
Prepaid insurance |
|
|
245 |
|
|
|
438 |
|
Interest receivable |
|
|
151 |
|
|
|
158 |
|
Other prepaid assets |
|
|
141 |
|
|
|
921 |
|
Value added tax receivable |
|
|
68 |
|
|
|
159 |
|
Total |
|
$ |
7,188 |
|
|
$ |
8,390 |
|
6. Property and Equipment
Property and equipment and related accumulated depreciation are as follows:
|
|
March 31, 2019 |
|
|
December 31, 2018 |
|
||
Leasehold improvements |
|
$ |
592 |
|
|
$ |
592 |
|
Furniture and fixtures |
|
|
120 |
|
|
|
120 |
|
Laboratory equipment |
|
|
81 |
|
|
|
81 |
|
Computer equipment |
|
|
118 |
|
|
|
108 |
|
|
|
|
911 |
|
|
|
901 |
|
Less: accumulated depreciation |
|
|
(236 |
) |
|
|
(201 |
) |
|
|
$ |
675 |
|
|
$ |
700 |
|
Depreciation expense was $35 for the three months ended March 31, 2019 and $136 for the year ended December 31, 2018.
7. Leases
The Company has entered into a number of operating leases, primarily for office space and commercial property. These leases have terms which range from six to 19 years, and generally include one or more options to terminate or renew. The termination options can reduce the lease term for periods ranging from five to 10 years, however the remaining lease terms do not represent these early termination dates as management have concluded that it is reasonably certain that the Company will not exercise these options. The renewal terms can extend the lease term for additional periods ranging from three to five years. These renewal options are represented in the remaining lease term as management have concluded that it is reasonably certain that the Company will exercise the renewal option. Certain leases contain variable lease payments, including payments based on an index or rate. Variable lease payments based on an index or rate are initially measured using the index or rate in effect at lease commencement. Certain agreements contain both lease and non-lease components. The Company has elected to separately account for these components in determining the lease liabilities and right-of-use assets. The Company’s lease agreements generally do not provide an implicit borrowing rate, therefore an internal incremental borrowing rate was determined based on information available at lease commencement date for the purposes of determining the present value of lease payments. The Company used the incremental borrowing rate on January 1, 2019 for all leases that commenced prior to that date. All operating lease expense is recognized on a straight-line basis over the lease term. The Company recognized $254 of operating lease costs for right-of-use assets during the three months ended March 31, 2019.
9
ITERUM THERAPEUTICS PLC
Notes to Condensed Consolidated Financial Statements
(In thousands, except share and per share data)
(Unaudited)
Information related to the Company’s right-of-use assets and related lease liabilities is as follows:
|
|
Three Months Ended |
|
|
|
March 31, 2019 |
|
||
Cash paid for operating lease liabilities |
|
$ |
190 |
|
Right-of-use assets obtained in exchange for new operating lease obligation (1) |
|
$ |
7,622 |
|
Weighted-average remaining lease term |
|
13.2 years |
|
|
Weighted-average discount rate |
|
|
7.6 |
% |
(1) All operating leases included above were held at January 1, 2019
Right-of-use assets and lease liabilities for the Company’s operating leases were recorded in the condensed consolidated balance sheet as follows, representing the Company’s right to use the underlying asset for the lease term (“Other assets”) and the Company’s obligation to make lease payments (“Other current liabilities” and “Other liabilities”):
|
|
March 31, 2019 |
|
|
Other assets |
|
$ |
7,504 |
|
|
|
|
|
|
Other current liabilities |
|
$ |
442 |
|
Other liabilities |
|
|
7,117 |
|
Total lease liabilities |
|
$ |
7,559 |
|
Future lease payments included in the measurement of lease liabilities on the condensed consolidated balance sheet as of March 31, 2019, for the following five fiscal years and thereafter were as follows:
Due in 12 month period ended March 31, |
|
|
|
|
2020 |
|
$ |
982 |
|
2021 |
|
|
1,017 |
|
2022 |
|
|
1,022 |
|
2023 |
|
|
1,033 |
|
2024 |
|
|
1,038 |
|
Thereafter |
|
|
6,420 |
|
|
|
$ |
11,512 |
|
Less imputed interest |
|
|
(3,953 |
) |
Total lease liabilities |
|
$ |
7,559 |
|
As of December 31, 2018, future minimum lease payments, as defined under the previous lease accounting guidance of ASC Topic 840, under non-cancelable operating leases for the following five fiscal years and thereafter were as follows:
Due in 12 month period ended December 31, |
|
|
|
|
2019 |
|
$ |
904 |
|
2020 |
|
|
1,020 |
|
2021 |
|
|
1,030 |
|
2022 |
|
|
985 |
|
2023 |
|
|
766 |
|
Thereafter |
|
|
2,356 |
|
|
|
$ |
7,061 |
|
10
ITERUM THERAPEUTICS PLC
Notes to Condensed Consolidated Financial Statements
(In thousands, except share and per share data)
(Unaudited)
Accrued expenses consist of the following:
|
|
March 31, 2019 |
|
|
December 31, 2018 |
|
||
Accrued clinical trial costs |
|
$ |
6,383 |
|
|
$ |
2,849 |
|
Accrued manufacturing expenses |
|
|
859 |
|
|
|
1,439 |
|
Accrued other expenses |
|
|
843 |
|
|
|
954 |
|
Accrued payroll and bonus expenses |
|
|
611 |
|
|
|
1,804 |
|
Total |
|
$ |
8,696 |
|
|
$ |
7,046 |
|
9. Shareholders’ Equity
The following tables present a reconciliation of our beginning and ending balances in shareholders’ equity for the three months ended March 31, 2019 and 2018:
|
|
Total Shareholders' Equity |
|
|
Shareholders' equity at January 1, 2019 |
|
$ |
71,622 |
|
Exercise of share options |
|
|
48 |
|
Share-based compensation expense |
|
|
540 |
|
Net loss |
|
|
(20,580 |
) |
Shareholders' equity at March 31, 2019 |
|
$ |
51,630 |
|
|
|
Total Shareholders' Equity |
|
|
Shareholders' equity at January 1, 2018 |
|
$ |
39,494 |
|
Issuance of Series B convertible preferred shares, net |
|
|
32,159 |
|
Share-based compensation expense |
|
|
149 |
|
Net loss |
|
|
(12,146 |
) |
Shareholders' equity at March 31, 2018 |
|
$ |
59,656 |
|
10. Share-Based Compensation
On November 18, 2015, the Company’s Board of Directors adopted and approved the 2015 Equity Incentive Plan (the “2015 Plan”), which authorized the Company to grant up to 223,424 ordinary shares in the form of incentive share options, nonstatutory share options, share appreciation rights, restricted share awards, restricted share units and other share awards. The types of share-based awards, including the rights amount, terms, and exercisability provisions of grants are determined by the Company’s Board of Directors. The purpose of the 2015 Plan is to provide the Company with the flexibility to issue share-based awards as part of an overall compensation package to attract and retain qualified personnel. On May 18, 2017, the Company amended the 2015 Plan to increase the number of ordinary shares available for issuance under the 2015 Plan by 219,605 shares to 443,029 shares.
On March 14, 2018, the Company’s Board of Directors adopted and approved the 2018 Equity Incentive Plan (the “2018 Plan”), which became effective upon the execution and delivery of the underwriting agreement related to our IPO in May 2018. No further grants will be made under the 2015 Plan. The ordinary shares underlying any options that are forfeited, cancelled, repurchased or are otherwise terminated by the Company under the 2015 Plan will not be added back to the ordinary shares available for issuance.
The 2018 Plan, adopted and approved on March 14, 2018, authorized the Company to grant up to 1,018,459 ordinary shares in the form of incentive share options, nonstatutory share options, share appreciation rights, restricted share awards, restricted share units, performance share awards, performance cash awards and other share awards. The types of share-based awards, including the amount, terms, and exercisability provisions of grants are determined by the Company’s Board of Directors. The ordinary shares underlying any options that are forfeited, cancelled, repurchased or are otherwise terminated by the Company under the 2018 Plan will be added back to the ordinary shares available for issuance under the 2018 Plan.
11
ITERUM THERAPEUTICS PLC
Notes to Condensed Consolidated Financial Statements
(In thousands, except share and per share data)
(Unaudited)
On December 5, 2018, pursuant to powers delegated to it by the Board of Directors of the Company, the Compensation Committee approved an increase in the number of ordinary shares available to be granted pursuant to the 2018 plan by 4% of the total number of shares of the Company’s issued share capital on December 31, 2018, being 574,081 ordinary shares.
Restricted Ordinary Shares
In connection with the Company’s formation, 413,110 restricted ordinary shares were issued on October 14, 2015 to the Company’s founders at par value. These ordinary shares are subject to various restrictions pursuant to ordinary share purchase agreements between the Company and each founder, including restrictions on transfer and a Company right of repurchase. The restricted ordinary shares were 25% vested as of October 14, 2016 and 1/36th of the remaining restricted ordinary shares vest on a monthly basis thereafter (subject to acceleration of vesting in connection with certain change of control transactions). A change in status occurred on November 18, 2015 when the founders became employees of the Company. The grant date of these shares is now considered to be November 18, 2015 when the fair value was $3.14 per share.
The Company records share-based compensation expense for the restricted ordinary shares based on the grant date fair value. The Company recorded an expense of $85 and $82 for the three months ended March 31, 2019 and 2018, respectively. Total unamortized compensation expense related to restricted ordinary shares was $175 and $510 as of March 31, 2019 and March 31, 2018, respectively, expected to be recognized over a weighted average period of 0.54 years and 1.54 years as of March 31, 2019 and March 31, 2018, respectively.
The following table summarizes restricted ordinary shares activity for the three months ended March 31, 2019:
|
|
Number of Shares |
|
|
Weighted Average Grant Date Fair Value per Share |
|
||
|
|
86,068 |
|
|
$ |
3.14 |
|
|
Granted |
|
|
— |
|
|
|
|
|
Vested |
|
|
(25,818 |
) |
|
$ |
3.14 |
|
Forfeited |
|
|
— |
|
|
|
|
|
Unvested at March 31, 2019 (unaudited) |
|
|
60,250 |
|
|
$ |
3.14 |
|
Share Options
The Company granted 442,500 share options to employees and directors during the three months ended March 31, 2019. The Company awarded 74,152 share options to employees during the three months ended March 31, 2018 under the 2018 Plan. These options were granted and priced upon execution of the underwriting agreement related to the IPO in May 2018. There were 984,913 and 221,553 unvested employee options outstanding as of March 31, 2019 and March 31, 2018, respectively. Total expense recognized related to the employee share options was $307 and $67 for the three months ended March 31, 2019 and 2018, respectively. Total unamortized compensation expense related to employee share options was $4,168 and $1,132 as of March 31, 2019 and March 31, 2018, respectively, which is expected to be recognized over a remaining average vesting period of 3.30 years and 3.27 years as of March 31, 2019 and March 31, 2018, respectively.
The assumptions that the Company used to determine the grant date fair value of employee and director options granted were as follows, presented on a weighted average basis:
|
|
|
Three Months Ended March 31, |
|
|||||
|
|
|
2019 |
|
|
2018 |
|
||
Volatility |
|
|
69.5% - 70.2% |
|
|
|
60% |
|
|
Expected term in years |
|
|
|
6.25 |
|
|
|
6.25 |
|
Dividend rate |
|
|
|
0% |
|
|
|
0% |
|
Risk-free interest rate |
|
|
2.44% - 2.57% |
|
|
|
1.63% |
|
|
Share price |
|
|
$5.80 - $6.80 |
|
|
|
— |
|
|
Fair value of option on grant date |
|
|
$3.74 - $4.41 |
|
|
|
— |
|
12
ITERUM THERAPEUTICS PLC
Notes to Condensed Consolidated Financial Statements
(In thousands, except share and per share data)
(Unaudited)
The following table summarizes the number of options outstanding and the weighted-average exercise price:
|
|
Number of Shares |
|
|
Weighted Average Exercise Price |
|
|
Weighted Average Remaining Contractual Life in Years |
|
|
Aggregate Intrinsic Value (in thousands) |
|
||||
Options outstanding December 31, 2018 |
|
|
665,219 |
|
|
$ |
9.31 |
|
|
|
8.93 |
|
|
395 |
|
|
Granted |
|
|
442,500 |
|
|
|
5.82 |
|
|
|
|
|
|
|
|
|
Exercised |
|
|
(15,395 |
) |
|
|
3.16 |
|
|
|
|
|
|
|
|
|
Forfeited |
|
|
(1,086 |
) |
|
|
9.44 |
|
|
|
|
|
|
|
|
|
Options outstanding March 31, 2019 |
|
|
1,091,238 |
|
|
$ |
7.98 |
|
|
|
9.27 |
|
|
|
1,956 |
|
Exercisable at March 31, 2019 (unaudited) |
|
|
106,325 |
|
|
$ |
4.59 |
|
|
|
8.25 |
|
|
|
425 |
|
Restricted share units (RSUs)
No RSUs were awarded to directors during the three months ended March 31, 2019. No RSUs were awarded or outstanding during the three months ended March 31, 2018.
The table below shows the number of RSUs granted covering an equal number of our ordinary shares and the weighted-average grant date fair value of the RSUs granted:
|
|
Number of Shares |
|
|
Weighted Average Grant Date Fair Value per Share |
|
||
RSUs outstanding December 31, 2018 |
|
|
36,924 |
|
|
$ |
13.00 |
|
Granted |
|
|
— |
|
|
|
|
|
Shares vested |
|
|
— |
|
|
|
|
|
Forfeited |
|
|
— |
|
|
|
|
|
RSUs outstanding March 31, 2019 |
|
|
36,924 |
|
|
$ |
13.00 |
|
The fair value of RSUs is determined on the date of grant based on the market price of our ordinary shares on that date. The fair value of RSUs is expensed ratably over the vesting period, which is generally one year for directors. Total expense recognized related to the RSUs was $119 for the three months ended March 31, 2019. Total unamortized compensation expense related to RSUs was $72 as of March 31, 2019, which is expected to be recognized over a remaining average vesting period of 0.15 years as of March 31, 2019.
The Company awarded 50,000 RSUs to certain employees during the three months ended March 31, 2019 which are subject to certain performance based vesting conditions (Performance RSUs). No Performance RSUs were awarded or outstanding during the three months ended March 31, 2018.
The table below shows the number of Performance RSUs granted covering an equal number of our ordinary shares and the weighted-average grant date fair value of the Performance RSUs granted:
|
|
Number of Shares |
|
|
Weighted Average Grant Date Fair Value per Share |
|
||
Performance RSUs outstanding December 31, 2018 |
|
|
— |
|
|
|
|
|
Granted |
|
|
50,000 |
|
|
$ |
8.21 |
|
Shares vested |
|
|
— |
|
|
|
|
|
Forfeited |
|
|
— |
|
|
|
|
|
Performance RSUs outstanding March 31, 2019 |
|
|
50,000 |
|
|
$ |