July 12, 2019
VIA EDGAR SUBMISSION
Securities and Exchange Commission
Division of Corporation Finance
100 F Street, NE
Washington, DC 20549
Attention: Joseph McCann
| Re: | Iterum Therapeutics plc |
| Registration Statement on Form S-3 |
| File No. 333-232569 |
| Request for Acceleration |
Ladies and Gentlemen:
Pursuant to Rule 461 under the Securities Act of 1933, as amended, Iterum Therapeutics plc hereby requests acceleration of the effective date of its Registration Statement on Form S-3 (File No. 333-232569), so that it may become effective at 4:30 p.m., Eastern time, on July 16, 2019, or as soon as practicable thereafter.
Very truly yours,
| By: | /s/ Corey N. Fishman | |
| Corey N. Fishman | ||
| President and Chief Executive Officer |